复方阿嗪米特肠溶片对胆囊炎患者外科治疗后消化不良的影响  

Clinical effects of compound azintamide enteric-coated tablets in treatment of cholecystitis patients with post-surgery dyspepsia

作　　者：周建军 

机构地区：[1]江山贝林医院药剂科,浙江省江山市324100

出　　处：《世界华人消化杂志》2015年第4期671-675,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨复方阿嗪米特肠溶片对胆囊炎患者外科治疗后消化不良的影响.方法:选取在浙江省江山贝林医院就诊的胆囊炎外科手术后消化不良的患者60例,随机分为研究组和对照组,每组30例.研究组口服复方阿嗪米特肠溶片,对照组服用安慰剂,150 mg/次,3次/d,连续服用4 wk.比较治疗前后两组患者消化不良症状积分、消化不良的总疗效率和两组患者的SF-NDI量表总评分.结果:两组患者治疗前消化不良积分及症状总积分情况比较,差异不具有统计学意义(P>0.05),研究组患者在治疗第28天食欲不振、早饱、嗳气、腹痛或腹部不适及症状总积分明显低于对照组,差异具有统计学意义(P<0.05);两组患者在治疗后1 wk,消化不良的总有效率差异不具有统计学意义(P>0.05),研究组中患者于治疗后2、3、4 wk消化不良的总有效率显效高于对照组,差异具有统计学意义(P<0.05);两组患者于治疗前、治疗后第7、14天的SF-NDI量表总评分差异不具有统计学意义(P>0.05),研究中患者于治疗后第21天及治疗后第28天的SFN D I量表总评分低于对照组,差异具有统计学意义(P<0.05).结论:复方阿嗪米特肠溶片可有效的改善胆囊炎患者外科手术后消化不良的症状,提高患者的生活质量.AIM： To investigate the clinical effects of compound azintamide enteric-coated tablets in the treatment of cholecystitis patients with postsurgery dyspepsia. METHODS： Sixty cholecystitis patients with post-surgery dyspepsia treated at our hospital were randomly divided into either a study group or a control group, with 30 cases in each group. The study group was given compound azintamide enteric-coated tablets, 150 mg each time, three times per day for 4 wk, and the control group was given matched placebo. The overall symptom score, the total rate of dyspepsia relief and the total score of SF-NDI scale were compared between the two groups before and after treatment.RESULTS： The overall symptom score and dyspepsia score did not differ significantly betweent wogroups of patients before treatment（P 〉 0.05）. After 28 days of treatment, the scores of dyspepsia symptoms such as anorexia, early satiety, belching, abdominal pain or discomfort and the overall symptom were significantly lower in the study group than in the control group（P 〈 0.05）. Although the to talrate of dyspepsi are lie fat one week after treatment showed no significant difference between the two groups（P 〉 0.05）, the rates at 2, 3, and 4 wk were significantly higher in the study group than in the control group（P 〈 0.05）. The total score of the SF-NDI scale showed no significant difference between the two groups before treatment, 7 d or 14 d after treatment（P 〉 0.05）, but was significantly lower on 21 d and 28 d in the study group than in the control group（P 〈 0.05）. CONCLUSION ： Compound azintamide enteric-coated tablets can effectively improve symptoms and life of quality in cholecystitis patients with post-surgery dyspepsia.

关 键 词：复方阿嗪米特肠溶片 胆囊炎 消化不良 

分 类 号：R657.4[医药卫生—外科学]