寻常型痤疮和脂溢性皮炎患者面部紫外线诱导红色荧光物质的荧光光谱学研究  

UV-induced red fluorescence on facial part of patients with acne vulgaris and seborrheic dermatitis： a fluorescence spectrum study

作　　者：黄文慧[1] 王宏伟[1] 赵永亮[1] 

机构地区：[1]中国医学科学院北京协和医院皮肤科,100730

出　　处：《中华医学美学美容杂志》2015年第1期37-40,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 测量寻常型痤疮患者和脂溢性皮炎患者面部紫外线诱导红色荧光物质（UVRF）的荧光光谱信号,了解UVRF的光学特性.方法 挤压提取寻常型痤疮和脂溢性皮炎患者面部含有UVRF的皮脂腺分泌物,以308 nm XeCl准分子激光作为激发光源,使用Ocean Optics USB2000＋F02243光谱仪测量6例寻常型痤疮和4例脂溢性皮炎患者面部UVRF的激光诱导荧光（LIF）光谱信号,并与原卟啉Ⅸ标准品的荧光光谱信号进行比较.结果 10例患者的UVRF标本荧光光谱分别出现1～4个峰,且均在680 nm处出现特征峰.原卟啉Ⅸ标准品的荧光光谱特征峰为688 nm且较UVRF特征峰平缓、宽大.结论 LIF检测系统可用于UVRF的荧光光谱学检测,UVRF与原卟啉Ⅸ有类似的光谱学特征,但是可能不是同种物质.Objective To measure the fluorescence spectral information of UVRF in the facial skin of patients with acne vulgaris and seborrheic dermatitis and to comprehend the optical properties of UVRF.Methods The lesions were squeezed to extract the sebaceous secretions containing UVRF in the facial skin.Ocean Optics USB2000 ＋F02243 Spectrometer and the 308nm excimer laser were used as an excitation light source to measure the signal of the LIF spectrum of UVRF in 6 acne vulgaris and 4 seborrheic dermatitis patients＇ facial part,compared with protoporphyrin Ⅸ.Results 1-4 peaks were detected in 10 patients＇ UVRF specimen respectively.The fluorescence spectra＇s characteristic peak of UVRF in 10 patients was at 680 nm.Protoporphyrin Ⅸ was at 688 nm and more gentle and generous than UVRF＇s characteristic peak.Conclusions LIF system can be used to detect the fluorescence spectroscopy of UVRF.UVRF has similar spectral characteristics to protoporphyrin Ⅸ,but it is not the same species.

关 键 词：痤疮 脂溢性皮炎 荧光光谱 红色荧光 激光诱导荧光 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]