尿液源性干细胞的研究进展  

RESEARCH PROGRESS OF URINE-DERIVED STEM CELLS

作　　者：陈春媛[1,2] 牛鑫[1] 汪泱[1,2] 

机构地区：[1]上海交通大学附属第六人民医院四肢显微研究所,上海200233 [2]南昌大学研究生院

出　　处：《中国修复重建外科杂志》2015年第3期372-376,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81170640)~~

摘　　要：目的对尿液源性干细胞(urine-derived stem cells,USCs)的分离培养、生物学特性及其在组织工程研究方面的应用进行综述。方法广泛查阅近年来国内外USCs相关文献,进行综合分析和归纳总结。结果目前用于分离筛选USCs的方法主要为贴壁法。USCs是一类具有较强增殖活性和多向分化潜能的成体干细胞,具有MSCs的各种生物学特性。结合使用适宜的生物支架材料和适当的生物活性因子,USCs可作为良好的种子细胞来源应用于组织器官修复重建。结论 USCs的研究前景广阔,其来源、个体差异性及其治疗价值等尚待深入研究。Objective To review the current progresses in purification strategies, biological characters, and the uses in tissue engineering of urine-derived stem cells （USCs）. Methods Recent relevant publications on the USCs were extensively reviewed, analyzed, and summarized. Results USCs, usually isolated by adherence screening method, are a population of mesenchymal stem cells （MSCs）--like somatic stem cells possessing robust self-renew and multi-potential differentiation ability. Combined with using appropriate biomaterials and biological molecules, USCs can be used as a good cell source for tissue engineering. Conclusion An alluring prospect exists on the USCs-related research. Further studies are required to investigate the origin, individual differences, and the therapeutic values of USCs.

关 键 词：尿液源性干细胞 分离培养 生物学特性 组织工程 种子细胞 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]