穴位注射卡介菌多糖核酸治疗支气管哮喘疗效观察  

Comparison of Therapeutic Effects between Acupoint-injection and Intramuscular-injection of Bacillus Calmette-Guerin Polysaccharide Nucleic Acid for Bronchial Asthma

作　　者：邹娴[1] 朱静[1] 康信忠[1] 胡伟勇[1] 王康[1] 彭中娟[1] 傅缨[1] 资晓飞[1] 

机构地区：[1]南昌大学第二附属医院中医科,南昌330006

出　　处：《针刺研究》2015年第1期65-69,共5页Acupuncture Research

基　　金：江西省卫生厅中医药科研基金项目(No.2011A070)

摘　　要：目的:观察卡介菌多糖核酸不同给药途径对支气管哮喘疗效的差异。方法:将60例支气管哮喘患者随机分为穴位注射组30例和肌肉注射组30例。穴位注射组将卡介菌多糖核酸注射液于双侧肺俞穴处行穴位注射,前15d每日1次,双侧肺俞穴各注射1mL,15d以后隔日注射1次,连续用药3个月;肌肉注射组将卡介菌多糖核酸注射液2mL注射于一侧臀部,给药时间同穴位注射组。比较治疗后两组肺功能及免疫球蛋白情况及停药3个月后两组症状、体征积分及哮喘控制测试(ACT)得分。结果:两组治疗后肺功能、IgE、IgG、症状体征积分、ACT得分均较治疗前改善(P<0.01),但穴位注射组的改善作用优于肌肉注射组(P<0.01,0.05),停药3个月后穴位注射组症状体征积分、ACT得分仍优于肌肉注射组(P<0.01)。结论:穴位注射较肌肉注射卡介菌多糖核酸能更快速、持久控制患者症状、体征,能更显著改善肺功能、降低IgE,是治疗支气管哮喘的有效方案。Objective To observe the curative effect of acupoint-injection and intramuscular-injection of Bacillus Calmette-Guerin （BCG） Polysaccharide Nucleic Acid for bronchial asthma. Methods Sixty patients with bronchial asthma were equally randomized into acupoint-injection group and intramuscular-injection group. For patients of the acupoint-injection group, 2 mL of BOG was injected into bilateral Feishu（BL 13, 1 mL for one side）once per day in the first 15 days, and once every other day in the rest 2.5 months except weekends. Intramuscular-injection was conducted at the lateral sites of the left or right buttock, 2 mL/time for each site, and the injection frequency was the same to that of the acupoint-injection. The therapeutic effect was as- sessed according to the standards of Guide Principles for Clinical Research of New Chinese Herbal Drugs （2002） and Asthma Group of Breathing Diseases of China Medical Association （2008）. Changes of FEV 1 （forced expiratory volume in the first se- cond）/FVC （forced vital capacity） and PEF% （peak expiratory flow） were detected using a pulmonary function detector. Serum IgA, IgM, IgG and IgE contents were assayed by using an autonomic biochemical analyzer. Results After 3 months＇ treatment, the scores of patients＇ symptoms and signs and serum IgE and IgG levels were significantly decreased in both muscular-injection and acupoint-injection groups （P〈0.01）, while asthma controlled test （ACT） scores FEV 1/FVC% and PEF% values were con- siderably increased in both groups compared to pre-treatment in the same one group （P〈0.01）. The effects of acupoint-injection were markedly superior to those of the intramuscular-injection in reducing clinical symptom-sign score, and serum IgE content, and in up-regulating ACT score, FEV 1/FVC% and PEF% levels （P〈0.05, P〈0. 01）. There were no significant differences in se- rum IgG, IgA and IgM levels between the two groups 3 months following the treatment （P〉0.05）. Conclusion Acupoint-in- jec

关 键 词：支气管哮喘 穴位注射 肌肉注射 卡介菌多糖核酸 血清免疫球蛋白 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]