不同HBeAg状态血清HBsAg滴度与HBV病毒载量相关关系的纵向分析  

A longitudinal analysis of the correlation between HBs Ag titers and serum HBV DNA concentrations according to the HBeAg status

作　　者：刘墨涵 陈钦艳[2,3] Tim Harrison 李海[2,3] 王学燕[2,3] 谭超[2,3] 杨庆利[2,3] 方钟燎[1,2,3] 

机构地区：[1]广西医科大学基础医学院,广西南宁530021 [2]广西壮族自治区疾病预防控制中心,广西南宁530028 [3]广西病毒性肝炎防制研究重点实验室 [4]英国伦敦大学学院(University College London)

出　　处：《应用预防医学》2015年第2期69-73,77,共6页Applied Preventive Medicine

基　　金：广西科学研究与技术开发计划项目(桂科攻1140003A-37)

摘　　要：目的探讨不同HBe Ag状态下血清HBs Ag滴度与病毒载量之间的相关关系。方法从由2 258名慢性乙肝病毒感染者组成的研究队列中随机抽取89名研究对象进行血清HBs Ag滴度与病毒载量相关关系的横断面和纵向分析。结果 HBe Ag阳性组HBs Ag滴度、病毒载量均显著高于HBe Ag阴性组(P<0.001);第一轮血清标本HBs Ag滴度与病毒载量呈正相关关系(r=0.642,P<0.001),这种相关关系均见于HBe Ag阳性组(r=0.449,P=0.013)和HBe Ag阴性组(r=0.300,P=0.018);且这种相关关系也见于第三轮HBe Ag阳性组和阴性组(r=0.782,P<0.001;r=0.279,P=0.028);在第二轮标本中,HBe Ag阳性组HBs Ag滴度与病毒载量呈正相关关系(r=0.625,P=0.001),而这种关系在HBe Ag阴性组接近显著性(r=0.229,P=0.078)。多因素分析表明病毒载量、HBe Ag状态和性别与血清HBs Ag滴度有关。结论血清HBs Ag滴度和HBV病毒载量之间的相关关系在HBe Ag阳性和阴性组之间没有差异。Objective To investigate the correlation between serum HBsAg titers and HBV DNA concentrations according to the HBeAg status. Methods Eighty-nine individuals were selected randomly from the Long An cohort of 2 258 subjects infected persistently with hepatitis B virus (HBV) for cross-sectional and longitudinal analysis of the correlation between serum HBsAg titers and viral loads. Results The serum HBsAg titers and viral loads of the persons with HBeAg positive were all significantly higher than those with HBeAg negative (P<0.001). In the first round of follow up, the serum HBsAg titer was positively correlated with serum HBV DNA (r=0.642, P<0.001) and this positive correlation was seen in both HBeAg positive and negative subjects(r=0.449, P=0.013;r=0.300, P=0.018, respectively). The correlation could also be seen in the third round samples (r=0.782, P<0.001for HBeAg positive group;r=0.279, P=0.028 for the HBeAg negative group, respectively).In the second round samples, the correlation was only seen in the HBeAg positive group and was not seen in HBeAg negative group (r=0.229, P=0.078). However, the P value is close to significance. The multiple linear regression analysis showed that sex, HBV DNA concentrations and HBeAg status were associated with the serum HBsAg titers Conclusion The correlation between serum HBsAg titers and viral loads may not differ between HBeAg positive and negative individuals.

关 键 词：乙型肝炎病毒 HBSAG HBEAG 病毒载量 相关关系 

分 类 号：R512.62[医药卫生—内科学]