Electrolytic reduction of Re(Ⅶ) using a flow type electrolysis cell and its possibility of radiopharmaceuticals application  

作　　者：张晓霞 赵羽佳 韦悦周 

机构地区：[1]School of Nuclear Science and Engineering, Shanghai Jiao Tong University

出　　处：《Nuclear Science and Techniques》2015年第1期98-102,共5页核技术（英文）

摘　　要：The electrochemical properties of perrhenate were studied in hydrochloric acid solution via cyclic voltammetry by disk glassy carbon electrode. The electroreduction of perrhenate was performed at a constant potential-0.33 V(vs. Ag/AgCl) with a potentiostat by a flow type electrolysis cell. It was found that the change of rhenium ion concentration before and after electrolysis was negligible. This means almost no rhenium or rhenium oxides were deposited on the carbon fiber electrode during the electroreduction. The rhenium ion solution changed from colorless into yellow-brown after electrolysis process. UV-Visible spectrophotometry was used to characterize the oxidation states of Re before and after electrolysis. Some obvious peaks were detected after electrolysis, indicating that Re(Ⅶ) was reduced to Re(V). The complex behavior and stability of Re(V)-HEDP were discussed for the purpose of electroreduction of Re(Ⅶ) or Tc(Ⅶ) on radiopharmaceuticals production.The electrochemical properties of perrhenate were studied in hydrochloric acid solution via cyclic voltammetry by disk glassy carbon electrode. The electroreduction of perrhenate was performed at a constant potential -0.33 V （vs. Ag/AgCl） with a potentiostat by a flow type electrolysis cell. It was found that the change of rhenium ion concentration before and after electrolysis was negligible. This means almost no rhenium or rhenium oxides were deposited on the carbon fiber electrode during the electroreduction. The rhenium ion solution changed from colorless into yellow-brown after electrolysis process. UV-Visible spectrophotometry was used to characterize the oxidation states of Re before and after electrolysis. Some obvious peaks were detected after electrolysis, indicating that Re（VII） was reduced to Re（V）. The complex behavior and stability of Re（V）-HEDP were discussed for the purpose of electroreduction of Re（VII） or Tc（VII） on radiopharmaceuticals production.

关 键 词：电解还原 放射性药物 电解槽 流动型 RE 药物应用 可见分光光度法 电化学性质 

分 类 号：TQ460.1[化学工程—制药化工] O646[理学—物理化学]