母亲高龄与儿童先天性心脏病关系的Meta分析  

A Meta analysis of relationship between advanced maternal age and congenital heart disease in children

作　　者：王珺[1] 张振业[1] 桂珂[1] 王声萍[1] 

机构地区：[1]华中师范大学医院公共卫生科,湖北武汉430079

出　　处：《现代预防医学》2015年第7期1214-1216,共3页Modern Preventive Medicine

摘　　要：目的利用Meta分析方法探讨母亲高龄因素与儿童先天性心脏病的关系,为早期预防提供科学依据。方法运用Stata10.0,对1994-2013年国内外有关母亲高龄与儿童先天性心脏病关系的病例对照研究相关文献进行Meta分析。结果纳入文献9篇,累计先天性心脏病病例19 201例,其中母亲为高龄的有3 026例,占15.76%;对照组74371例,其中母亲为高龄的有11 410例,占15.34%。合并OR值为1.13,95%置信区间：1.07~1.18。结论儿童先天性心脏病的发生可能与母亲高龄有关,应提倡育龄妇女选择最佳年龄段生育,降低先心病的发生率。Objective To explore the relationship between advanced maternal age and congenital heart disease in children by meta-analysis, provide a scientific basis for early prevention.Methods A meta-analysis was performed with Stata 10.0 software to analyze the case-control study data of maternal advanced age and congenital heart disease from 1994 to 2013. Results 9 literatures were finally included in meta-analysis, including 19201 cases and 74371 controls. There were 3026 older mothers in cases（15.76%）, 11410 in controls（15.34%）. OR=1.13 and 95%CI： 1.07-1.18. Conclusion The occurrence of congenital heart disease was correlated with advanced maternal age. Women of childbearing age to should be promoted to select the best reproductive ages,in order to reduce the incidence of congenital heart disease.

关 键 词：母亲高龄 儿童 先天性心脏病 META分析 

分 类 号：R17[医药卫生—妇幼卫生保健]