Divergent pathways of β,γ-unsaturated α-diazocarbonyl compounds catalyzed by dirhodium and Lewis acids catalysts separately or in combination  

作　　者：Xin-Fang Xu Michael P.Doyle 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science,Dushu Lake Campus,Soochow University [2]Department of Chemistry and Biochemistry.University of Maryland,College Park

出　　处：《Chinese Chemical Letters》2015年第2期227-232,共6页中国化学快报（英文版）

基　　金：the National Institutes of Health(No.GM 46503);the National Science Foundation(No.CHE-1212446);the starting funding from Soochow University and Key Laboratory of Organic Synthesis of Jiangsu Province

摘　　要：β,γ-Unsaturated a-diazocarbonyl compounds possess two reactive sites for electrophilic addition-one at the diazo carbon and the other at the vinylogous γ-position.Controlled by catalyst,divergent transformations are achieved starting from the same starting materials,either by Lewis acid-catalyzed addition or by dirhodium-catalyzed metal carbene reactions.In select cases two catalysts working in combination or in sequence provide a relay for cascade transformations.In this review,we summarize advances in catalyst-dependent divergent transformations of β,γ-unsaturated α-diazocarbonyl compounds and highlight the potential of this exciting research area and the many challenges that remain.β,γ-Unsaturated a-diazocarbonyl compounds possess two reactive sites for electrophilic addition-one at the diazo carbon and the other at the vinylogous γ-position.Controlled by catalyst,divergent transformations are achieved starting from the same starting materials,either by Lewis acid-catalyzed addition or by dirhodium-catalyzed metal carbene reactions.In select cases two catalysts working in combination or in sequence provide a relay for cascade transformations.In this review,we summarize advances in catalyst-dependent divergent transformations of β,γ-unsaturated α-diazocarbonyl compounds and highlight the potential of this exciting research area and the many challenges that remain.

关 键 词：Divergent synthesis β γ-Unsaturated α-diazocarbonyl compounds Metal carbene（carbenoid） Dirhodium Lewis acid catalyst 

分 类 号：O643.36[理学—物理化学]