A facile approach to tricyclo[6.4.0.0^(4,9)]-dodecane framework  

作　　者：Dong Wang William E.Crowe 

机构地区：[1]Longwood Biopharmaceuticals,Inc. [2]Tianjin International Joint.Academy of Biomedicine [3]Department of Chemistry,Louisiana State University

出　　处：《Chinese Chemical Letters》2015年第2期238-242,共5页中国化学快报（英文版）

基　　金：Financial support from TianJin Municipal Science and Technology Commission(No.11ZCKFSY06200) is greatly acknowledged

摘　　要：The unusual tricyclo[6.4.0.0^4,9]dodecane framework was constructed in eight linear steps in 13%overall yield.An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed.The key steps involve a Robinson annulation,a base induced decarboxylation and epimerization in a single step,and an intramolecular alkylation.The unusual tricyclo[6.4.0.0^4,9]dodecane framework was constructed in eight linear steps in 13%overall yield.An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed.The key steps involve a Robinson annulation,a base induced decarboxylation and epimerization in a single step,and an intramolecular alkylation.

关 键 词：Tricyclo[6.4.0.0^4 9]dodecane Vinigrol Robinson annulation Bicyclo[3.3.1]nonane 

分 类 号：O621.3[理学—有机化学]