An efficient synthesis of benzo[b]benzofurano[2,3-e]-[1,6]naphthyridine-8-ones  

作　　者：Dao-Lin Wang Dan Wu Wei Zhao Yong-Yang Wang Jian-Ying Wu 

机构地区：[1]College of Chemistry and Chemical Engineering,Liaoning Key Laboratory of Synthesis and Application of Functional Compound,Bohai University

出　　处：《Chinese Chemical Letters》2015年第2期251-254,共4页中国化学快报（英文版）

基　　金：financial support from the Science and Technology Department of Liaoning Province(No.2011220022)

摘　　要：An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be obtained from alkylation of 4-bromomethylquinoline-2-ones with salicylonitrile and subsequent Thorpe-Ziegier isomerization,with aromatic aldehydes under p-TsOH as catalyst in good yields.An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been developed via Pictet-Spengler reaction of 4-（3-aminobenzofuran-2-yl）quinoline-2-ones,which could be obtained from alkylation of 4-bromomethylquinoline-2-ones with salicylonitrile and subsequent Thorpe-Ziegier isomerization,with aromatic aldehydes under p-TsOH as catalyst in good yields.

关 键 词：4-Bromomethylquinoline-2-one Salicylonitrile Benzo[b]benzofurano[2 3e][1 6]naphthyridine-8-one Thorpe-Ziegler isomerization Pictet-Spengler reaction 

分 类 号：O626[理学—有机化学]