Controlled acid hydrolysis and kinetics of flavone C-glycosides from trollflowers  

作　　者：Mian Dou Xi-Hui He Yan Sun Fang Peng Jiang-Yun Liu Li-Li Hao Shi-Lin Yang 

机构地区：[1]College of Pharmaceutical Sciences,Soochow University [2]School of Pharmaceutical Sciences,Peking University Health Science Center

出　　处：《Chinese Chemical Letters》2015年第2期255-258,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.81274190);Jiangsu Provincial Science and Technology Commission(No.BE2012649);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

摘　　要：Acid hydrolysis mechanisms of orientin-2＂-O-galactopyranoside（OGA）,orientin and other flavone C-glycosides in the trollflowers[Trollius chinensis Bunge） were studied in this report for the first time.Hydrolysis parameters including temperature,acidity,solvent and reaction time were comprehensively investigated.OGA could be hydrolyzed to orientin,followed by an isomerization to isoorientin via a reversible Wessely-Moser rearrangement reaction under stronger acidic conditions.A first-order kinetic model fitted the hydrolysis process of OGA well.Under the optimal hydrolysis conditions of 80 ℃,1.0 mol/L H^＋ and 7 h reaction time,about 77%OGA was transformed to orientin with no detectable isoorientin.These results could be helpful for better understanding of the acid hydrolysis kinetics of flavone C-glycosides,as well as the preparation of these valuable components under controlled acid hydrolysis conditions.Acid hydrolysis mechanisms of orientin-2＂-O-galactopyranoside（OGA）,orientin and other flavone C-glycosides in the trollflowers[Trollius chinensis Bunge） were studied in this report for the first time.Hydrolysis parameters including temperature,acidity,solvent and reaction time were comprehensively investigated.OGA could be hydrolyzed to orientin,followed by an isomerization to isoorientin via a reversible Wessely-Moser rearrangement reaction under stronger acidic conditions.A first-order kinetic model fitted the hydrolysis process of OGA well.Under the optimal hydrolysis conditions of 80 ℃,1.0 mol/L H^＋ and 7 h reaction time,about 77%OGA was transformed to orientin with no detectable isoorientin.These results could be helpful for better understanding of the acid hydrolysis kinetics of flavone C-glycosides,as well as the preparation of these valuable components under controlled acid hydrolysis conditions.

关 键 词：Flavone C-glycoside Orientin Trollius chinensis Acid hydrolysis Kinetic 

分 类 号：O643.1[理学—物理化学]