病毒感染与儿童哮喘急性发作相关性分析  

The Correlation Analysis between Virus Infection and Acute Asthmatic Attack in Children

作　　者：范如艳[1] 范楚平[1] 潘俊秀[1] 陈礼娟[1] 肖志兵[1] 刘婵[1] 

机构地区：[1]南华大学附属郴州市第一人民医院郴州市儿童哮喘防治技术研发中心,湖南省郴州市423000

出　　处：《医学理论与实践》2015年第6期701-703,共3页The Journal of Medical Theory and Practice

基　　金：郴州市科技局资助重点项目(CZ2013065)

摘　　要：目的:了解病毒感染与儿童哮喘急性发作之间的相关性。方法:应用直接免疫荧光法(DIF),对实验组(367例哮喘急性发作患儿)和对照组(403例哮喘缓解期患儿)鼻咽分泌物进行7种病毒抗原检测。结果:实验组239例检出至少1种病毒,总检出率65.1%。呼吸道合胞病毒(RSV)检出最多,为154例,检出率42.0%,其余,依次为副流感病毒Ⅲ(PIVⅢ)31例(8.4%),腺病毒(ADV)25例(6.8%),流感病毒A(IFA)11例(3.0%),流感病毒B(IFB)9例(2.5%),副流感病毒Ⅰ(PIVⅠ)5例(1.4%),副流感病毒Ⅱ(PIVⅡ)4例(1.1%)。6个月以下年龄组阳性率最高,为67.5%。RSV季节性较明显,主要集中在冬春季节(10月至次年4月)。对照组60例检出至少1种病毒,总检出率14.9%。呼吸道合胞病毒(RSV)检出最多,为39例,检出率9.7%,其余,依次为副流感病毒Ⅲ(PIVⅢ)11例(2.7%),腺病毒(ADV)5例(1.2%),流感病毒A(IFA)3例(0.7%),流感病毒B(IFB)1例(0.2%),副流感病毒Ⅰ(PIVⅠ)1例(0.2%),副流感病毒Ⅱ(PIVⅡ)0例(0%)。两组比较差异有显著性意义(P<0.01)。结论:病毒感染与儿童哮喘急性发作有密切相关性,RSV是引起婴幼儿哮喘急性发作的主要病毒,主要集中在冬春季节。Objective：To explore the correlation analysis between virus infection and acute asthmatic attack in children.Methods：Totally seven-hundred seventy children with asthma were recruited,and divided into experimental group（n=367）with acute asthmatic attack and control group（n=403）with asthma in remission stage.Seven virus infections were identified by immunofluorescence testing of nasopharyngeal swabs was collected during respiratory episodes.Results：There are at least one virus was detected in experimental group（239/367,65.1%）and control group（60/403,14.9%）.Respiratory syncytial virus（RSV）was the most（154/367,42.0%in experimental group and 39/403,9.7%in control group）,and the others were parainfluenzaⅢ（31/367,8.4% and 11/403,2.7%,respectively）,adenovirus（25/367,6.8% and 5/403,1.2%,respectively）,influenza A virus（11/367,3.0% and 3/403,0.7%,respectively）,influenza B virus（9/367,2.5%and 1/403,0.2%,respectively）,parainfluenzaⅠ（5/367,1.4%and 1/403,0.2%,respectively）,parainfluenzaⅡ（4/367,1.1% and 0/403,0%,respectively）.It is significantly difference between experimental group and control group（P〈0.01）.The detection rates of virus was highest in children aged〈6month（67.5%）.RSV infection has obvious seasonal character,most illness occurs in yearly outbreak in the winter and early spring months,e.g.October to April.Conclusion：There is a close relationship between virus infection and acute asthmatic attack in children.RSV is the major causes of acute asthmatic attack in infant,and the peak of onset was in winter and spring.

关 键 词：儿童 哮喘 感染 病毒 

分 类 号：R725.6[医药卫生—儿科]