儿童哮喘急性发作支气管肺泡灌洗液病毒病原学分析  

The Bronchoalveolar Lavage Fluid Viral Pathogens Analysis of Acute Asthmatic Attack in Children

作　　者：潘俊秀[1] 范楚平[1] 范如艳[1] 陈礼娟[1] 肖志兵[1] 刘婵[1] 

机构地区：[1]南华大学附属郴州市第一人民医院郴州市儿童哮喘防治技术研发中心,湖南省郴州市423000

出　　处：《医学理论与实践》2015年第6期706-708,共3页The Journal of Medical Theory and Practice

基　　金：郴州市科技局资助重点项目(2012cj084;CZ2013065)

摘　　要：目的:了解病毒感染与儿童哮喘急性发作相关性。方法:应用直接免疫荧光法(DIF),对实验组(67例哮喘急性发作患儿)和对照组(73例哮喘缓解期患儿)支气管肺泡灌洗液进行7种病毒抗原检测。结果:实验组51例检出至少1种病毒,总检出率76.1%。呼吸道合胞病毒(RSV)检出最多,为32例,检出率47.8%,其余,依次为副流感病毒Ⅲ(PIVⅢ)7例(10.4%),腺病毒(ADV)5例(7.5%),流感病毒A(IFA)3例(4.5%),流感病毒B(IFB)2例(3.0%),副流感病毒Ⅰ(PIVⅠ)1例(1.5%),副流感病毒Ⅱ(PIVⅡ)1例(1.5%)。对照组12例检出至少1种病毒,总检出率16.4%。呼吸道合胞病毒(RSV)检出最多,为9例,检出率12.3%,其余,依次为副流感病毒Ⅲ(PIVⅢ)2例(2.7%),腺病毒(ADV)1例(1.4%),流感病毒A(IFA)、流感病毒B(IFB)、副流感病毒Ⅰ(PIVⅠ)、副流感病毒Ⅱ(PIVⅡ)均未检测到。两组比较差异有显著性意义(P<0.01)。结论:病毒感染与儿童哮喘急性发作有密切相关性,RSV是引起儿童哮喘急性发作的主要病毒。Objective：To explore the correlation analysis between virus infection and acute asthmatic attack in children.Methods：Totally one-hundred forty children with asthma were recruited,and divided into experimental group（n=67）with acute asthmatic attack and control group（n=73）with asthma in remission stage.Seven virus infections were identified by immunofluorescence testing of bronchoalveolar lavage fluid（BALF）.Results：There are at least one virus was detected in experimental group,（51/67,76.1%）and control group（12/73,16.4%）.Respiratory syncytial virus（RSV）was the most（32/67,47.8%in experimental group and 9/73,12.3%in control group）,and the others were parainfluenzaⅢ（7/67,10.4% and 2/73,2.7%,respectively）,adenovirus（5/67,7.5% and 1/73,1.5%,respectively）,influenza A virus（3/67,4.5% and 0/73,0%,respectively）,influenza B virus（2/67,3.0% and 0/73,0%,respectively）,parainfluenzaⅠ（1/67,1.5% and 0/73,0%,respectively）,parainfluenza Ⅱ（1/67,1.5% and 0/73,0%,respectively）.It is significantly difference between experimental group and control group（P〈0.01）.Conclusion：There is a close relationship between virus infection and acute asthmatic attack in children.RSV is the major causes of acute asthmatic attack in children.

关 键 词：儿童 哮喘 支气管肺泡灌洗液 感染 病毒 

分 类 号：R725.6[医药卫生—儿科]