干细胞移植治疗脊髓损伤后排尿障碍的可行性  

Feasibility of stem cell transplantation in treatment of urination disorders after spinal cord injury

作　　者：倪剑书 曹乃龙[1] 谷宝军[1] 

机构地区：[1]上海交通大学附属上海市第六人民医院泌尿外科,上海200233

出　　处：《临床泌尿外科杂志》2015年第3期280-284,共5页Journal of Clinical Urology

基　　金：国家自然科学基金资助项目(编号81370862)

摘　　要：一直以来,脊髓损伤因其高致残率而被视为医学界的一大难题。在脊髓损伤的诸多并发症中,泌尿系统并发症是脊髓损伤患者最主要的死因之一。由于损伤的神经细胞无法再生,目前对于脊髓损伤患者排尿障碍的各种治疗效果都十分有限。然而,随着干细胞研究的不断进展,越来越多的实验表明干细胞移植治疗可以改善脊髓损伤后的排尿功能,提示该方法具有一定的可行性。本文就近年来关于干细胞移植治疗脊髓损伤后排尿障碍的研究进展,从常用干细胞种类、干细胞移植治疗的机制、干细胞移植时间、干细胞移植途径几个方面做一综述,并提出通过干细胞体外分化得到能够分泌5-羟色胺的神经细胞来进行移植治疗脊髓损伤后排尿障碍的新思路。Spinal cord injury（SCI）is a challenging medical problem for its high rates of disability and mortality.Among all the complications of SCI,urinary system is one of the main causes of death for SCI patients.As mature neural cells cannot be regenerated,bladder functional recovery after SCI is limited.However,in recent years,an increasing number of studies suggest that transplanted stem cells can improve the urination disorders of SCI rats.In this review,we will cover common sorts of stem cells,mechanisms of stem cell transplantation therapy,time and ways of transplantation.In the end,we put forward the prospect of transplanting serotoninergic neurons differentiated from stem cells in vitro to treat urination disorders after SCI.

关 键 词：干细胞移植 脊髓损伤 排尿障碍 5-羟色胺 

分 类 号：R694[医药卫生—泌尿科学]