慢性应激抑郁模型大鼠海马凋亡率的不对称性改变  

Asymmetrical changes of apoptosis rate of hippocampus in rat model with chronic stress-induced depression

作　　者：窦立敏[1] 吴鹤鸣[2] 王东[1] 

机构地区：[1]南京医科大学附属江宁医院神经外科,江苏省211100 [2]中国人民解放军第八一医院神经外科

出　　处：《江苏医药》2015年第4期380-382,共3页Jiangsu Medical Journal

摘　　要：目的探讨抑郁大鼠模型左右海马细胞凋亡率的改变。方法 SD大鼠20只均分为两组:模型组采用慢性轻微应激刺激21d建立大鼠抑郁模型;对照组不作处理。采用流式细胞术测定大鼠海马细胞凋亡率的变化。结果模型组大鼠左侧海马细胞凋亡率高于对照组[(10.97±0.78)%vs.(6.63±1.23)%](P<0.05),而两组大鼠右侧海马细胞凋亡率无统计学差异(P>0.05)。结论抑郁症大鼠海马细胞凋亡呈不对称性改变。Objective To investigate the changes of cell apoptosis rate of the hippocampus in rats models with chronic mild stress-induced depression.Methods Twenty SD rats were equally divided into two groups.The rats in group A were given chronic mild stress for three weeks to establish the depression models,while those in group B were taken as the normal controls.Cell apoptosis rates in both sides of the hippocampus were detected by flow cytometry.Results Cell apoptosis rate in the left hippocampus was higher in group A than that in groyp B[（10.97±0.78）%vs.（6.63±1.23）%]（P〈0.05）,which in the right hippocampus was not significantly different between two groups（P〉0.05）.Conclusion An asymmetrical hippocampus injury exists in the rats with chronic mild stress-induced depression.

关 键 词：抑郁 海马 凋亡 大鼠 

分 类 号：R338[医药卫生—人体生理学]