^(99)Tc^m-TF与^(99)Tc^m-HL91心肌乏氧显像评估SMI心肌活力进展  

Recent Advances of Hypoxia Imaging with ^(99)Tc^m-tetrofosmin and ^(99)Tc^m-HL91 in the Evaluation of SMI Myocardial Viability

作　　者：付巍[1] 卢彦祺 肖国有[2] 

机构地区：[1]桂林医学院附属医院核医学科,广西桂林541001 [2]广西壮族自治区肿瘤医院核医学科,广西南宁530021

出　　处：《标记免疫分析与临床》2015年第3期241-243,253,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：SPECT心肌灌注显像是评价冠心病心肌缺血的无创方法。99Tcm-TF作为新型心肌显像剂,标记简便无需水浴,本底清除快,有效缩短待检时间,诊断心肌缺血/梗死效果佳,但低估了心肌细胞的活性。18F-FDG PET心肌显像是评判心肌活力有效方法,但因其普及率低、费用昂贵,存在一定的检查失败率等因素而无法广泛使用。99Tcm-HL91是近年来研制的乏氧组织显像剂,能直接与乏氧心肌组织结合,乏氧心肌显著摄取,正常心肌摄取少,坏死心肌不摄取。SMI是冠心病发生发展过程中的一种表现,是冠心病其最危险的因素之一,但又常被忽视。SMI患者行99Tcm-TF联合99Tcm-HL91乏氧显像,对心肌缺血范围、严重程度及心肌活力的判断、合理治疗方案的选择、预后疗效的判定及减轻患者综合医疗负担等方面均有积极作用。SPECT myocardial perfusion imaging is a noninvasive method of assessment of coronary heart disease（ Myocardial Ischemia）. As a new type of myocardial imaging agent,99Tcm-tetrofosmin is easy to label with99 mTc,background removed fast,effectively shorten the waiting time for examination,and better in diagnosis of myocardial ischemia / infarction,but is underestimate the activity of myocardial cells.18F-FDG PET myocardial perfusion imaging is an effective method in evaluation of myocardial activity. Since the low penetration,high cost and a certain rate of failure in examination,it is not widely used.99Tcm-HL91 is a hypoxia tissue imaging agent and can be combined with hypoxia tissue directly,obviously ingested by hypoxia myocardium,seldom ingested by normal myocardium and barely ingested by necrotic myocardium. SMI is a kind of performance in the development process of coronary heart disease,which is one of the most dangerous factors of coronary heart disease. Hypoxia imaging with99Tcm-tetrofosmin and99Tcm-HL91 in SMI patients play a positive role in the judgment of range of myocardial ischemia and myocardial activity,the choice of reasonable treatment plan,and the judgment of prognosis and reducing the financial burden for patients.

关 键 词：放射性核素显像 无症状心肌缺血 细胞低氧 细胞存活 锝99Tcm-TF 99Tcm-HL91 脱氧葡萄糖 

分 类 号：R817.4[医药卫生—影像医学与核医学]