老年慢性阻塞性肺疾病急性期血浆P物质测定的临床意义  

Clinical significance of substance P determination of acute stage blood in elderly people with chronic obstructive pulmonary disease

作　　者：刘瑜[1] 陈红芬[1] 熊文[1] 郑世良[1] 

机构地区：[1]潍坊医学院附属医院,山东潍坊261031

出　　处：《中国卫生检验杂志》2015年第5期683-685,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨老年慢性阻塞性肺疾病急性期(AECOPD)血浆P物质(SP)测定的临床意义。方法以39例AECOPD老年患者和32例COPD稳定期老年患者为研究对象,30例老年健康体检者为对照组,采用酶联免疫吸附法(ELISA)检测各组血浆SP浓度,计算BODE指数评分,比较COPD患者血浆SP浓度和BODE指数相关性。观察AECOPD老年患者1年死亡率和急性发作者血浆SP浓度情况。结果 AECOPD老年患者血浆SP浓度显著高于稳定期COPD老年患者及老年健康对照组(P<0.01);而稳定期COPD老年患者血浆SP浓度明显高于老年健康对照组(P<0.01)。AECOPD老年患者血浆SP浓度与BODE指数评分呈正相关(P<0.01)。死亡和1年内2次以上急性发作者血清SP浓度明显升高(P<0.05)。结论 AECOPD老年患者血浆SP水平可以判断COPD病情严重程度和预后,对AECOPD老年患者的治疗有所帮助。Objective To investigate the clinical significance of substance P（ SP） determination of acute stage blood in elderly people with chronic obstructive pulmonary disease（ COPD）. Methods 39 elderly cases with AECOPD and 32 elderly cases with COPD in stable period were chosen as the research object,and 30 healthy elder examinee were selected as control group.To detect the concentration of serum SP of each group by ELISA,apply the BODE index and investigate the relations between the levels of SP in elder patients with COPD and BODE index. The mortality at 1 year and the plasma concentration of SP of elder patients with AECOPD were observed. The SPSS 17 statistical software was used for statistical analysis. Rusults The plasma concentration of SP in AECOPD group was significantly higher than that in stable-period-group and the control group（ P 0. 01）. And the plasma concentration of SP in stable-period-group of COPD was also significantly higher than the control group（ P 0. 01）. The plasma concentration of SP of elder people with AECOPD has a positive relationship with the BODE index（ P 0. 01）. The mortality at 1 year and the plasma concentration of SP in elder patients with AECOPD were significantly higher（ P 0. 05）. Conclusion The plasma concentration of SP in elder patients with AECOPD was significantly higher,which played an important part in the development of COPD and can be used to judge the disease severity and prognosis of COPD and be useful for the treatment of elder patients with AECOPD.

关 键 词：慢性阻塞性肺疾病 P物质 肺功能试验 

分 类 号：R563[医药卫生—呼吸系统]