超敏C反应蛋白联合CKMB检测在手足口病患儿早期心肌损伤的预防价值  

Hypersensitive c-reactive protein and CKMB detection in prevention early myocardial injury in children with handfoot-mouth disease

作　　者：董建红 刘国风 蒋永升[2] 董春红 

机构地区：[1]青岛市妇女儿童医院,青岛266034 [2]山东大学医学院,济南250000 [3]青岛市中心医院肿瘤科,266042

出　　处：《中国优生与遗传杂志》2015年第2期119-120,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨手足口病(hand-foot-mouth disease,HFMD)患儿超敏C反应蛋白(hypersensitivity c-reactive protein,hs-CRP)联合CK-MB检测对早期心肌损伤的预测价值。方法检测438例早期手足口病患儿治疗前后血清hs CRP与CK-MB水平,并与45例健康儿童检测结果进行对比。结果 HFMD患儿血清hs-CRP与CK-MB水平显著高于健康对照组,经治疗后hs-CRP与CK-MB水平明显下降。同时,心电图检测异常者hs-CRP和CK-MB改变亦较心电图正常者明显。结论 hs-CRP为HFMD心肌损伤病变早期的敏感指标,CK-MB对判断HFMD所致的心肌损害有高度特异性,联合检测CK-MB与hs-CRP可以为手足口病的早期诊治提供一定的科学依据。Objective：To investigate the predictive value of hs-CRP（hypersensitivity c-reactive protein）and CK-MB in early myocardial injury in children with hand-foot-mouth disease. Methods：Serum samples of 438 cases of children with early hand-foot-mouth disease and 45 cases of healthy children were collected and used to detect the levels of hs-CRP and CK-MB. Results：The levels of hs-CRP and CK-MB in patients with HFMD were significantly higher than those of the control group,and were dramatically decreased after treatment. In addition,HFMD patients with abnormal ECG findings show higher hs-CRP and CK-MB,compared with those of normal ECG. Conclusion：Hs-CRP is an important marker in the prediction of early myocardial lesions caused by HFMD. CK-MB is highly specific to judge myocardial injury. The combined detection of myocardial enzyme CK-MB and hs-CRP can provide some scientific basis for early diagnosis and treatment of hand- foot-mouth disease.

关 键 词：HS-CRP CK-MB 手足口病 早期心肌损伤 

分 类 号：R725.1[医药卫生—儿科]