Nrf2基因单核苷酸多态性与急性高原病相关性研究  

Association between single nucleotide polymorphism in Nrf2 gene and acute mountain sickness

作　　者：耿倩雯[1] 张继航[1] 覃军[1] 黄岚[1] 晋军[1] 

机构地区：[1]第三军医大学新桥医院心血管内科,全军心血管病研究所,重庆400037

出　　处：《军事医学》2015年第2期105-107,共3页Military Medical Sciences

基　　金：国家卫生部卫生行业科研专项基金资助项目(201002012)

摘　　要：目的探讨中国汉族人群中Nrf2基因多态性与急性高原病(AMS)易感性的关系。方法采用巢式病例研究方法,以603名急进3700 m高原的中国汉族青年男性为研究对象,根据路易斯湖评分系统(LLSS)分为病例组(n=369)和对照组(n=234),采用Sequenom Mass Array质谱阵列技术检测两组人群Nrf2基因位点rs10497511和rs2364722的基因多态性。结果病例组与对照组中rs10497511和rs2364722位点分别检测出T、C和A、G等位基因;两位点等位基因频率在两组间差异无统计学意义(P>0.05)。进一步对2个位点的基因型共显性模型、显性模型和隐性模型分析也未提示差异有统计学意义(P>0.05)。结论 Nrf2基因rs10497511和rs2364722位点多态性与中国汉族男性人群AMS发病可能无相关性。Objective To explore the correlation of single nucleotide polymorphism（ SNP） in Nrf2 gene with acute mountain sickness（ AMS） among Han populations in China. Methods As a nested case-control study,603 Chinese Han young men who had been quickly exposed to 3700 m were adopted and divided into case group and control group（ 369 vs234,respectively） by Lake Louise Self-assessment Scoring System（ LLSS）. The Sequenom Mass Array system was used to detect the SNPs of rs10497511 and rs2364722 in Nrf2 gene. Results Alleles of rs10497511 and rs2364722 were respectively detected in both case and control groups,which were T-C and A-G. Statistically significant difference was not found in allele frequencies（ P〉0. 05）. Further analysis showed that there was still no significant difference between the codominant,dominant and recessive genotype models（ P〉0. 05）. Conclusion rs10497511 and rs2364722 of Nrf2 gene may not be related to susceptibility to AMS in Chinese Han populations.

关 键 词：急性高原病 Nrf2基因 多态性 单核苷酸 

分 类 号：R594.3[医药卫生—内科学]