中医中药治疗川崎病临床疗效的系统评价及Meta分析  

The clinical effects of traditional Chinese medicine on Kawasaki disease：a systematic review of randomized controlled trials and Meta analysis

作　　者：万琦[1] 邓玉萍[1] 鄢素琪[1] 汤建桥[1] 李红[1] 王芳[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心,湖北武汉430016

出　　处：《中国中西医结合急救杂志》2015年第2期124-127,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：湖北省武汉市临床医学科研项目（WZ13D13）

摘　　要：目的：系统评价中医中药治疗川崎病的有效性和安全性。方法通过计算机检索PubMed、Cochrane图书馆、中国学术期刊全文数据库（CNKI）、维普数据库、万方数据库，收集1990年至2013年国内公开发表的有关中医中药治疗川崎病的随机对照临床试验（RCT）文章，并进行质量评价，按照纳入和排除标准进行文献筛选，干预措施为中医药治疗和西医常规治疗。采用RevMan 5.2软件对纳入研究进行系统评价。结果共检索到相关文献212篇，最终纳入13篇文献共计656例川崎病患儿。Meta分析显示：中医中药治疗川崎病总有效率优于西药治疗，差异有统计学意义〔优势比（OR）＝3.58，95%可信区间（95%CI）为2.16-5.93，总体效益检验Z＝4.94，P＜0.00001〕；而中医中药治疗组在改善冠状动脉改变方面和西药组比较差异无统计学意义（OR＝2.03，95%CI为0.74-5.62，总体效益检验Z＝1.37，P＝0.17）。结论中医中药联合西医常规治疗川崎病较单纯西药治疗对提高患者临床疗效有一定的优势。Objective To systemically evaluate the clinical therapeutic effect and safety of traditional Chinese medicine on Kawasaki disease. Methods Through retrieval of the reports in PubMed, the Cochrane Library, China National Knowledge Internet （CNKI）, VIP database, Wanfang database by computer, the correlative articles of clinically randomized controlled trials （RCTs） published in China during the period from 1990 to 2013 were collected, and their quality evaluation was made. All the articles were screened according to inclusion and exclusion criteria, in which interventions were traditional Chinese medicine therapy and conventional western treatment. The articles selected were assessed with the software of RevMan 5.2. Results There were 212 articles searched out, but only 13 articles, 656 children with Kawasaki disease were conformed to the inclusion criteria. The Meta analysis indicated that the total effective rate in the traditional Chinese medicine group was superior to the group treated with western medicine. The difference in the curative effects between the two groups had notable significance [odds ratio （OR） = 3.58, 95%confidence interval （95%CI） was 2.16-5.93, test for overall effect Z=4.94, P〈0.000 01]. No difference was seen in the curative effect of improving coronary artery changes between the traditional Chinese medicine group and western medicine control group （OR=2.03, 95%CI was 0.74-5.62, test for overall effect Z=1.37, P=0.17）. Conclusion The clinical therapeutic effect of traditional Chinese medicine on Kawasaki disease is superior to that treated by western medicine.

关 键 词：中医药 川崎病 随机对照试验 系统评价 

分 类 号：R711.33[医药卫生—妇产科学]