胺碘酮治疗充血性心力衰竭合并室性心律失常的效果  

Effect of Amiodarone in the treatment of congestive heart failure com-bined with ventricular arrhythmia

作　　者：罗玉钊[1] 陈炎[1] 何洪[1] 

机构地区：[1]广东省高州市人民医院药剂科,广东高州525200

出　　处：《中国医药导报》2015年第8期57-60,共4页China Medical Herald

摘　　要：目的研究分析胺碘酮应用于充血性心力衰竭伴室性心律失常的治疗效果。方法选择2013年10月-2014年10月于高州市人民医院接受治疗的74例充血性心力衰竭伴室性心律失常患者,利用抽签取样法将其均分为两组,其中37例患者采取常规抗心衰加利多卡因的方法进行治疗,设为对照组;37例患者在常规抗心力衰竭的基础上应用胺碘酮进行治疗,设为观察组。观察两组患者24 h动态心电图检查的结果、NYHA心功能分级、临床疗效以及不良反应等情况,并进行对比分析。结果观察组患者的临床总有效率[94.59%（35/37）]显著高于对照组[78.38%（29/37）],差异有统计学意义（P〈0.05）。治疗后,两组患者QTc有所延长、QTd及心功能分级有所降低,而观察组患者QTc明显长于对照组,QTd及心功能分级明显低于对照组,差异均有高度统计学意义（均P〈0.01）。观察组患者不良反应发生率（10.81%）与对照组（8.11%）比较,差异无统计学意义（P〉0.05）。结论胺碘酮用于充血性心力衰竭合并室性心律失常的治疗效果满意,能够明显改善心功能,抗室性心律失常的作用较强,并且患者的安全性、耐受性良好,可作为临床治疗的首选药物进行推广。Objective To study and analyze the effect of Amiodarone in the treatment of congestive heart failure combined with ventricular arrhythmia. Methods Seventy four patients with congestive heart failure combined with ventricular arrhythmia from October 2013 to October 2014 treated in the People＇s Hospital of Gaozhou City were selected and divided into two groups averagely. 37 patients taken regular anti-heart failure combined lidocaine treatment were set as the control group; 37 patients on the basis of conventional anti-heart failure in application of Amiodarone treatment were set as observation group. The result of 24-hour dynamic electrocardiogram inspection, the NYHA heart function classification, clinical curative effect and adverse reaction of two groups were observed and comparison analyzed. Results The clinical total effective rate of the observation group [94.59%（35/37）] was significantly higher than that of the control group [78.38%（29/37）], the difference was statistically significant（P〈0.05）. After treatment, the QTc of patients in two groups were extended, QTd and cardiac function classification were reduced, QTc of patients in the observation group was significantly longer than that of the control group; QTd and cardiac function classification were lower than the control group obviously, the differences were statistically significant（all P 〈0.01）. The adverse effects rate in the observation group（10.81%） and the control group（8.11%） had no statistically significant difference（P〉0.05）. Conclusion Amiodarone has satisfied curative effect in the treatment of congestive heart failure combined with ventricular arrhythmia, can significantly improve the cardiac function, strong resistance to the effect of ventricular arrhythmia, and safe, well tolerated, can be used as a first choice drug and promotion in clinical treatment.

关 键 词：胺碘酮 充血性心力衰竭 室性心律失常 疗效 

分 类 号：R541.75[医药卫生—心血管疾病]