205例药品不良反应报告分析  

Analysis of 205 cases of adverse drug reactions

作　　者：翟爱华[1] 张白[1] 王琦[1] 

机构地区：[1]济南市第五人民医院药剂科,山东济南250022

出　　处：《中国医药导报》2015年第8期109-112,共4页China Medical Herald

摘　　要：目的了解济南市第五人民医院(以下简称"我院")药品不良反应(ADR)发生情况,分析规律和特点,以期提高ADR监测水平,促进临床合理用药。方法对我院2013年上报国家药品不良反应监测网的205例ADR报告,从患者的性别、年龄、给药途径、药品种类、累及器官或系统、临床表现及上报人群的职业等方面,进行回顾性统计与分析。结果我院ADR报告中60岁以上患者较多,共88例(占42.93%),女性患者(154例,占75.12%)明显多于男性(51例,占24.88%);静脉给药引发ADR最多,共188例(占91.71%);引发ADR的药品共涉及12类、65个品种,其中,抗感染药物包括13个品种,居首位(20.00%),抗感染药物同时居ADR上报例数首位,共计80例(39.02%);ADR累及器官或系统包含10类,主要是皮肤及附件损害,共57例(27.81%)。ADR上报人群的职业主要是医师,占86.83%。结论医护人员应重视ADR监测工作,严格按照药品说明书使用药品,减少ADR的发生。Objective To explore the incidence of adverse drug reactions（ADRs） in the Fifth People＇s Hospital of Ji＇nan City（＂our hospital＂ for short）, analyze the regularity and characteristics, in order to improve ADRs monitoring levels for clinical rational drug use. Methods 205 ADRs cases collected from the National Adverse Drug Reaction Monitoring Network reported by our hospital in 2013 were analyzed retrospectively and statistically in aspects of gender, age, route of administration, drugs types, organs or systems, clinical manifestations and occupation of reporting people involved in ADRs. Results In the total ADRs cases, patients aged over 60 were 88 cases（42.93%）, female accounted for higher proportion（154 cases, 75.12%） than male（51 cases, 24.88%）. 188（91.71%） ADRs cases were induced by intravenous administration. There were 12 classes 65 varieties drugs involved in ADRs, in which anti-infective drugs ranked the first, including 13 varieties, accounting for 20.00%; while the ADRs of anti-infective drugs ranked the first,accounted for 39.02%（80 cases）. Organ or system involved in ADRs included 10 categories, which was mainly manifested as lesions of the skin and its appendents（57 cases, 27.81%）. Physicians（86.83%） were the primarily reporting people. Conclusion Health care workers should pay attention to ADR monitoring and use drugs strictly accordance with the instructions, in order to reduce the occurrence of ADRs.

关 键 词：药品不良反应 合理用药 分析 

分 类 号：R969.3[医药卫生—药理学]