肾病患儿联合检测尿中三种蛋白的临床意义  

Clinical significance of joint detection for three kinds of protein in urine of children with nephropathy

作　　者：杨忠实[1] 李君光[2] 

机构地区：[1]长春市宽城区医院,130051 [2]北华大学医学院附属医院

出　　处：《中国实用医药》2015年第5期34-35,共2页China Practical Medicine

摘　　要：目的探索尿白蛋白(Alb)、免疫球蛋白G(Ig G)和β2-微球蛋白(β2-MG)联合测定在肾脏疾病(肾病)患儿早期诊断和病变部位的价值。方法 127例肾脏疾病患儿,其中急性肾炎61例,为肾炎组,肾病综合征66例,为肾病组,另选取正常健康小儿50例,为对照组。采用RIA法对三组尿液中的Alb、Ig G和β2-MG进行测定。结果肾炎组和肾病组尿中的Alb、Ig G明显高于对照组(P<0.01);肾病组尿中的β2-MG明显高于对照组和肾炎组(P<0.01)。结论尿中的Alb、Ig G和β2-MG联合测定能高灵敏早期反映肾脏的损伤,且能区分是肾小球还是肾小管的损害,并与病情呈正相关。Objective To explore the value of joint detection of urinary albumin（Alb）, immune globulin G（Ig G）, and β2-microglobulin（β2-MG） in early diagnosis and diseased region of children with nephropathy. Methods There were 127 children with nephropathy, and 61 cases of them had acute nephritis, as nephritis group, 66 cases of then had nephrotic syndrome, as nephropathy group. Another 50 healthy children were taken as control group. RIA method was applied to detect Alb, Ig G, and β2-MG in urine of the three groups. ResultsThe levels of Alb, Ig G, and β2-MG were obviously higher in the nephritis group and nephropathy group than the control group（P〈0.01）. The nephropathy group had higher β2-MG than the control group and nephritis group（P〈0.01）. Conclusion The joint detection of Alb, IgG, and β2-MG in urine can reflect renal injury early with high sensitivity, and it can distinguish glomerulus injury and kidney tubules injury with positive correlation with illness condition.

关 键 词：肾病综合征 肾炎 免疫球蛋白G 白蛋白 Β2-微球蛋白 

分 类 号：R726.9[医药卫生—儿科] R446.12[医药卫生—临床医学]