生物柴油副产物甘油间接法合成1,3-二羟基丙酮  

Indirect synthesis of 1,3-dihydroxyacetone from glycerol of biodiesel byproduct

作　　者：向华明 文彬[1] 李严红 王磊[1,2] 

机构地区：[1]中国科学院新疆理化技术研究所,新疆乌鲁木齐830011 [2]中国科学院大学,北京100039

出　　处：《现代化工》2015年第3期116-119,共4页Modern Chemical Industry

基　　金：新疆维吾尔自治区自然科学基金(2012211A101)

摘　　要：利用甘油和苯甲醛为原料,通过缩合、氧化、水解三步法合成了1,3-二羟基丙酮(1,3-Dihydroxyacetone,简写为DHA)。对合成工艺进行了优化改进,用对甲苯磺酸铜取代腐蚀性强、副反应多的质子酸作催化剂,用甲苯替换高毒性的苯作结晶溶剂,考察了不同阶段的影响因素。优化后单步反应累计收率从18.7%提高到34.6%,并且对环境的污染减少,工艺简单安全。用GS-MS、NMR、IR对中间体和目标产物进行了定量和定性分析。1, 3-Dihydroxyacetone can be prepared from glycerol and benzaldehyde in three steps, namely, aeetalization, oxidation, hydrolysis. The reaction conditions are optimized. Copper p-toluene sulfonate is used to replace the Bronsted acid as catalyst and toluene is employed as crystal solvent instead of the poisonous benzene. The influencing factors of each step are studied. Under the optimum condition, the yield of target product is improved from 18.7% to 34. 6%. This process is more environmentally friendly and safer. The characterization of target products and intermediates are analyzed by means of GM-MS, IR, and NMR.

关 键 词：甘油 苯甲醛 1 3-二羟基丙酮 DHA 

分 类 号：TQ645.51[化学工程—精细化工]