妊娠期肝内胆汁淤积症在细胞分子水平上的认识进展  

Progress in study on the cellular and molecular level of intrahepatic cholestasis of pregnancy

作　　者：胡海军[1] 李佳平[1] 

机构地区：[1]川北医学院附属医院妇产科,四川南充637000

出　　处：《川北医学院学报》2015年第1期128-131,共4页Journal of North Sichuan Medical College

摘　　要：妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)为高危妊娠,是妊娠期特有疾病。虽然对孕妇预后良好,仍会出现早产、羊水胎粪污染、胎儿宫内窘迫、无明显先兆的胎死宫内等不良妊娠结局,故近年来越来越受到重视。然而ICP发生机制仍不清楚,可能与遗传因素,生殖激素,免疫耐受失衡以及环境因素有关,有待于进一步深入研究与探求。Intrahepatic cholestasis of pregnancy （ICP） is a high-risk pregnancy and it is specific. Although the prognosis is good for pregnant women,there are bad results such as premature birth, meconium stained amniotic fluid, fetal distress and no obvious sign of fetal death,etc. So in recent years more and more attentions are paid to ICP. The ICP mechanism,however,remains unclear and may be associated with genetic factors, reproductive hormones, immune tolerance instability, as well as environmental factors, which needs further research and exploration.

关 键 词：胆汁淤积 肝内 妊娠并发症 妊娠结局 分子机制 

分 类 号：R714.2[医药卫生—妇产科学]