Semi-quantitative Assessment of Brain Maturation by Conventional Magnetic Resonance Imaging in Neonates with Clinically Mild Hypoxic-ischemic Encephalopathy  

作　　者：Jie Gao Qin-Li Sun Yu-Miao Zhang Yan-Yan Li Huan Li Xin HOU Bo-Lang Yu Xi-Hui Zhou Jian Yang 

机构地区：[1]Department of Diagnostic Radiology, The First Hospital of Xi'an Jiaotong University, Xi'an, Shannxi 710061, China [2]Department of Neonatology, The First Hospital of Xi'an Jiaotong University, Xi'an, Shannxi 710061, China

出　　处：《Chinese Medical Journal》2015年第5期574-580,共7页中华医学杂志（英文版）

基　　金：The grant from National Natural Science Foundation of China （No. 81471631 and 81171317 to Jian Yang） and The 2011 New Century Excellent Talent Support Plan from Ministry of Education of China （DWYXSJ11000007 to Jian Yang）, the Fund for the National Clinical Key Specialty from the Ministry of Health of China.

摘　　要：Background：Mild hypoxic-ischemic encephalopathy （HIE） injury is becoming the major type in neonatal brain diseases.The aim of this study was to assess brain maturation in mild HIE neonatal brains using total maturation score （TMS） based on conventional magnetic resonance imaging （MRI）.Methods：Totally,45 neonates with clinically mild HIE and 45 matched control neonates were enrolled.Gestated age,birth weight,age after birth and postmenstrual age at magnetic resonance （MR） scan were homogenous in the two groups.According to MR findings,mild HIE neonates were divided into three subgroups：Pattern Ⅰ,neonates with normal MR appearance; Pattern Ⅱ,preterm neonates with abnormal MR appearance; Pattern Ⅲ,full-term neonates with abnormal MR appearance.TMS and its parameters,progressive myelination （M）,cortical infolding （C）,involution of germinal matrix tissue （G）,and glial cell migration bands （B）,were employed to assess brain maturation and compare difference between HIE and control groups.Results：The mean of TMS was significantly lower in mild HIE group than it in the control group （mean ± standard deviation [SD] 11.62 ± 1.53 vs.12.36 ± 1.26,P 〈 0.001）.In four parameters of TMS scores,the M and C scores were significantly lower in mild HIE group.Of the three patterns of mild HIE,Pattern Ⅰ （10 cases） showed no significant difference of TMS compared with control neonates,while Pattern Ⅱ （22 cases）,Ⅲ （13 cases） all had significantly decreased TMS than control neonates （mean ± SD 10.56 ± 0.93 vs.11.48 ± 0.55,P 〈 0.05; 12.59 ± 1.28 vs.13.25 ± 1.29,P 〈 0.05）.It was M,C,and GM scores that significantly decreased in Pattern Ⅱ,while for Pattern Ⅲ,only C score significantly decreased.Conclusions：The TMS system,based on conventional MRI,is an effective method to detect delayed brain maturation in clinically mild HIE.The conventional MRI can reveal the different retardations in subtle structures and development processes among the different pBackground：Mild hypoxic-ischemic encephalopathy （HIE） injury is becoming the major type in neonatal brain diseases.The aim of this study was to assess brain maturation in mild HIE neonatal brains using total maturation score （TMS） based on conventional magnetic resonance imaging （MRI）.Methods：Totally,45 neonates with clinically mild HIE and 45 matched control neonates were enrolled.Gestated age,birth weight,age after birth and postmenstrual age at magnetic resonance （MR） scan were homogenous in the two groups.According to MR findings,mild HIE neonates were divided into three subgroups：Pattern Ⅰ,neonates with normal MR appearance; Pattern Ⅱ,preterm neonates with abnormal MR appearance; Pattern Ⅲ,full-term neonates with abnormal MR appearance.TMS and its parameters,progressive myelination （M）,cortical infolding （C）,involution of germinal matrix tissue （G）,and glial cell migration bands （B）,were employed to assess brain maturation and compare difference between HIE and control groups.Results：The mean of TMS was significantly lower in mild HIE group than it in the control group （mean ± standard deviation [SD] 11.62 ± 1.53 vs.12.36 ± 1.26,P 〈 0.001）.In four parameters of TMS scores,the M and C scores were significantly lower in mild HIE group.Of the three patterns of mild HIE,Pattern Ⅰ （10 cases） showed no significant difference of TMS compared with control neonates,while Pattern Ⅱ （22 cases）,Ⅲ （13 cases） all had significantly decreased TMS than control neonates （mean ± SD 10.56 ± 0.93 vs.11.48 ± 0.55,P 〈 0.05; 12.59 ± 1.28 vs.13.25 ± 1.29,P 〈 0.05）.It was M,C,and GM scores that significantly decreased in Pattern Ⅱ,while for Pattern Ⅲ,only C score significantly decreased.Conclusions：The TMS system,based on conventional MRI,is an effective method to detect delayed brain maturation in clinically mild HIE.The conventional MRI can reveal the different retardations in subtle structures and development processes among the different p

关 键 词：Brain Maturation Hypoxic-ischemic Encephalopathy Magnetic Resonance Imaging NEONATES 

分 类 号：Q581[生物学—生物化学] S852.33[农业科学—基础兽医学]