PDR中血管内皮生长因子与纤维化相关细胞因子的相关性  

Research the correlation of vascular endothelial growth factor and fibrosis-related cytokines in proliferative diabetic retinopathy

作　　者：魏美琪 陈晓隆[1] 冯雪梅[1] 杨宏伟[1] 盖春柳[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,中国辽宁省沈阳市110000

出　　处：《国际眼科杂志》2015年第3期454-458,共5页International Eye Science

摘　　要：血管内皮生长因子在视网膜新生血管生成中是必不可少的重要诱导因子。增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)患者视网膜新生血管形成后,随着病情进一步加重,可造成纤维血管膜形成、视网膜前膜的纤维化加重,造成牵拉性视网膜脱离。目前研究认为,细胞因子具有促进成纤维细胞增殖、移动、黏附和分泌细胞外基质的功能,在糖尿病环境状态下,转变至促纤维化状态,导致了细胞外基质的积聚和纤维化。本文对血管内皮生长因子与纤维化相关细胞因子相关性的研究现状予以综述。Vascular endothelial growth factor is indispensable inducing factor in retinalangiogenesis. After the retinal neovascularization of proliferative diabetic retinopathy（ PDR） patients, it can cause fibrovascular membrane formation, epiretinal membrane fibrosis increased,resulting in traction retinal detachment with further aggravate the condition. The recent research suggests that cytokines promote fibroblast proliferation,movement, adhesion, and secretion of extracellular matrix functions in the diabetic state of the environment changes to profibrogenic state, resulting in the accumulation and fibrosis of extracellular matrix. This paper reviewed the status quo of the correlation between vascular endothelial growth factor and fibrosis- related cytokine.

关 键 词：增殖性糖尿病性视网膜病变 血管内皮生长因子 细胞因子 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]