高湿地区中老年人群胸苷激酶1水平差异  

Experimental study on the change in serum thymidine kinase 1 in middle-aged and elderly people in high humidity area

作　　者：林薇 胡娟[2] 薛怀裕 呼永河[4] 

机构地区：[1]第三军医大研究生大队,重庆400038 [2]成都军区临床医学检验中心 [3]巴中市第一人民医院 [4]成都军区总医院

出　　处：《中华老年医学杂志》2015年第3期319-321,共3页Chinese Journal of Geriatrics

基　　金：全军医学科技”十二五”重点项目（BWS11J067）

摘　　要：目的 了解高湿地区不同年龄段中老年人群血清中胸苷激酶1（TKI）浓度,探讨世居高湿地区人群血清TKI浓度水平,以及细胞异常增殖发生的高危年龄,查出病因,及时给予干预治疗.方法 采用增强化学发光法检测世居年平均湿度83％地区的128例中老年人群（49～89岁）血清TKI浓度. 结果 中年人群（49～岁）和老年人群（60～岁）血清TK1浓度分别为（1.3894±0.5004） pmol/L、（1.6516±0.8685）pmol/L,中年人群血清TKI浓度低于老年人群（t=2.159,P＜0.05）;但中老年人群TK1阳性率差异无统计学意义（χ^2=1.894,P＞0.05）;同时将老年人群分为3个年龄段：60～岁,70～岁,80～89岁,其血清TKI浓度分别为（1.7854±0.9736） pmol/L、（1.5345±0.7039） pmol/L、（1.4420±0.7354） pmol/L,将其与中年人群比较,发现60～岁人群高于中年人群（t=2.369,P＜0.05）;老年人群其余年龄段与中年人群相比以及老年人群三个年龄段相比较,差异无统计学意义（P＞0.05）;每个年龄段不同性别之间血清TKI浓度差异无统计学意义（P＞0.05）.结论 高湿地区老年人群细胞异常增殖水平高于该地区中年人群,应注重老年人群的健康体检.Objective To investigate serum level of thymidine kinase 1 （TK1） in middle-aged and elderly people in high humidity area,and explore the high risk age of cell abnormal proliferation and the cause.Methods Serum level of TK1 was measured with enhanced chemiluminescence in 128 cases aged 49-89 years living in the region with an average humidity of 83%.People were divided into control group （n =52,aged 49-59 years） and experimental group （n=76,aged 60 years and over）.Results Serum TK1 level was lower in control group than in the experimental group [（1.3894±0.504） pmol/L vs.（1.6518±0.8685） pmol/L,t=2.159,P〈0.05].There was no significant difference in positive rate of TK1 between control and experimental groups （9.62 % vs.18.42%,χ^2 =1.894,P〉0.05）.Experimental group was subgrouped into three age groups：aged 60-69 years,70 79 years and 80 89 years group.In the three age groups,serum TK1 levels were （1.7854 ±0.9736） pmol/L,（1.5345 ± 0.7039） pmol/L and （1.4420 ± 0.7354） pmol/L respectively.Compared with control group,serum TK1 level was increased in aged 60-69 years group （t=2.369,P 〈0.05）,with no significant difference in serum TK1 level between control group and the other two age groups （all P〉0.05）.Meanwhile,there was no significant difference in serum TK1 level among the three age groups （all P〉0.05）.Conclusions Serum TK1 concentration is higher in elderly people than in middle-aged people,which shows that the abnormal cell proliferation is higher in elderly people than in middle-aged people.We should pay more attention to physical examination in the elderly people aged 60-69 years.

关 键 词：胸苷激酶 湿地 

分 类 号：R446.6[医药卫生—诊断学]