瞿麦的化学成分研究  

Chemical constituents from Dianthus superbus

作　　者：傅旭阳[1] 田均勉[1] 

机构地区：[1]西北农林科技大学理学院,陕西杨凌712100

出　　处：《中草药》2015年第5期645-648,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(31300283)

摘　　要：目的研究石竹科植物瞿麦Dianthus superbus全草的化学成分。方法利用硅胶柱、Sephadex LH-20凝胶柱和HPLC等色谱手段进行分离纯化,通过NMR、MS等光谱手段进行结构鉴定。结果从瞿麦全草石油醚萃取部位中分离得到9个化合物,分别鉴定为5-羟基-7,3′,4′-三甲氧基二氢黄酮（1）、5,3′-二羟基-7,4′-二甲氧基二氢黄酮（2）、5,4′-二羟基-7,3′-二甲氧基二氢黄酮（3）、β-菠甾醇（4）、胖大海素A（5）、（24R）-环阿屯-25-烯-3β,24-二醇（6）、（24S）-环阿屯-25-烯-3β,24-二醇（7）、豆甾-7-烯-3β-醇（8）和羟基二氢博伏内酯（9）。结论化合物1~9均为首次从瞿麦中分离得到。Objective To investigate the chemical constituents of Dianthus superbus.Methods The chemical constituents were isolated from 95% alcohol extract of D.superbus by silica gel column chromatography,Sephadex LH-20 column chromatography,and HPLC.Their chemical structures were elucidated on the basis of 1D NMR and ESI-MS spectroscopic analyses.Results Nine compounds including three flavanoids,two sterols,three triterpenes,and one γ-lactone were isolated.Their structures were identified as 5-hydroxy-7,3′,4′-trimethoxyflavanone（1）,5,3′-dihydroxy-7,4′-dimethoxyflavanone（2）,5,4′-dihydroxy-7,3′-dimethoxyflavanone（3）,β-spinasterol（4）,sterculin A（5）,（24R）-cycloart-25-ene-3β,24-diol（6）,（24S）-cycloart-25-ene-3β,24-diol（7）,stigmast-7-en-3β-ol（8）,and hydoxydihydrobovolide（9）.Conclusion All the compounds（1—9） are isolated from D.superbu for the first time.

关 键 词：瞿麦 5-羟基-7 3′ 4′-三甲氧基二氢黄酮 β-菠甾醇 胖大海素A (24R)-环阿屯-25-烯-3β 24-二醇 

分 类 号：R284.1[医药卫生—中药学]