代谢组学技术及其在中医药研究中的应用  

Application of metabonomics in study on traditional Chinese medicine

作　　者：赵珊[1] 王鹏程[1] 冯健[1] 陈自力[1] 王秋红[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学中药学教育部重点实验室,黑龙江哈尔滨150040

出　　处：《中草药》2015年第5期756-765,共10页Chinese Traditional and Herbal Drugs

基　　金：国家"973"项目课题(2013CB531801)

摘　　要：代谢组学是继基因组学、蛋白组学和转录组学之后出现的一门新兴的"组学",目前已在生命科学领域得到了广泛的应用并展现出良好的前景。代谢组学通过分析外界刺激后生物体内相对分子质量较低的代谢物的全面变化,来认识生物体的生理和病理状态。代谢组学为中药安全性评价,中药复方的物质基础与作用机制研究以及中医证候的认识提供了强有力的技术支持。Metabonomics is an emerging ＂omics＂ following genomics,proteomics,and transcriptomics.It has been widely used in the field of life science,and shows hopeful prospects.The principle of metabonomics is to understand the physiological and pathological state of the organism by comprehensive analysis of the metabolites with low relative molecular weight after external stimuli.In the present,metabonomics is widely used in the studies on traditional Chinese medicine（TCM）,and provides the strong technical support for the TCM safety evaluation,the material basis and mechanism of Chinese medicinal formula,and understanding the recognition of TCM syndrome and sign.

关 键 词：代谢组学 安全性评价 中药复方 证候 中医药 

分 类 号：R285[医药卫生—中药学]