甘精胰岛素联合盐酸二甲双胍治疗2型糖尿病疗效观察  

Effect of insulin glargine combined with metformin hydrochloride in the treatment of type 2 diabetes mellitus

作　　者：梁秋波[1] 刘小莲[1] 江浩[1] 

机构地区：[1]广东省信宜市人民医院重症医学科,525300

出　　处：《齐齐哈尔医学院学报》2015年第5期674-675,共2页Journal of Qiqihar Medical University

摘　　要：目的比较甘精胰岛素联合口盐酸二甲双胍与门冬胰岛素30治疗2型糖尿病(T2DM)的疗效和安全性。方法选择48例口服降糖药血糖控制不理想的T2DM患者,随机分成两组,每组24例,A组采用甘精胰岛素联合盐酸二甲双胍治疗,B组采用门冬胰岛素30治疗。对两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2h PG)、低血糖事件发生率、体质指数(BMI)及糖化血红蛋白(Hb A1c)变化进行比较。结果治疗12周后,两组患者FPG、2h PG、Hb Alc均较治疗前明显下降(P<0.05),而BMI则无明显变化(P>0.05),各组间比较差异无统计学意义(P>0.05)。两组低血糖发生率均为4.17%(1/24)。结论门冬胰岛素30治疗与甘精胰岛素联合二甲双胍均可有效控制血糖,而且低血糖发生率低,安全可靠。Objective We were to compare the efficacy and safety of insulin glargine combined with mefformin hydrochloride in the treatment of type 2 diabetes mellitus. Methods The 48 T2DM patients failed to control hyperglycemia by orally taken anti -diabetes drugs were randomly divided into A and B groups, 24 cases in each group. The patients in A and B groups were treated with insulin glargine combined with mefformin hydrochloride and insulin aspart 30 respectively. Fasting plasma glucose （FPG） , two - hour postprandial plasma glucose （2 hPG）, incidence of hypoglycemia, body mass index （BMI） and hemoglobin Ale （HbAlc） before and after treatment in the two groups were compared. Results 12 weeks later after treatment, the level of FPG, 2 hPG and HbA1 c in the two groups were decreased significantly （ P 〈 O. 05 ）, however, there were no statistically significance between A and B groups （ P 〉 0. 05 ）. Both the incidence of hypoglycemia in the two groups were 4. 17% （1/24）. Conclusions Both insulin aspart 30 and insulin glargine combined with mefformin hydrochloride are effective for the treatment of type 2 diabetes mellitus with less hypoglycemia.

关 键 词：2型糖尿病 甘精胰岛素 盐酸二甲双胍 门冬胰岛素30 

分 类 号：R977.15[医药卫生—药品]