槲皮素的降压作用及其机制研究  

Antihypertensive effects and mechanisms of quercetin

作　　者：程瑾[1] 胡顺安[1] 

机构地区：[1]襄阳市中心医院(湖北文理学院附属医院),湖北襄阳441021

出　　处：《实用药物与临床》2015年第3期334-337,共4页Practical Pharmacy and Clinical Remedies

摘　　要：槲皮素是一种天然多酚黄酮类化合物,富含于苹果、洋葱、浆果等食物中,与心血管疾病负相关。最近动物和人类试验均表明,槲皮可以降低高血压个体的血压,机制可能涉及抗氧化应激、抑制血管紧张素转化酶(ACE)活性,以内皮依赖性和非依赖性方式改善血管内皮功能等。本综述将系统阐述槲皮素的降压作用及其相关机制。Quercetin,a natural polyphenolic flavonoid found in plant,such as apples,onions and berries,is inversely related to cardiovascular disease.Recent work using hypertensive animals and humans indicates a decrease in blood pressure after quercetin supplementation.A number of proposed mechanisms may be responsible such as antioxidant effects,inhibition of angiotensin-converting enzyme activity,and improved endothelium-dependent and-independent function.The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure-lowering effect

关 键 词：槲皮素 高血压 氧化应激 内皮功能 

分 类 号：R285[医药卫生—中药学]