左旋肉碱对肥胖患者血脂水平影响的meta分析  

A meta-analysis of effect of L-carnitine on lipid levels in obese patients

作　　者：仝晨均[1] 付晓丽[2] 付余[2] 宋金露 

机构地区：[1]郑州大学药学院,郑州450001 [2]郑州大学公共卫生学院,郑州450001

出　　处：《郑州大学学报（医学版）》2015年第2期214-217,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金项目H2610

摘　　要：目的：采用meta分析明确左旋肉碱与肥胖患者血脂水平的关系。方法：按照系统评价的要求,检索左旋肉碱用于减肥的随机对照试验,对纳入的研究进行质量评价和meta分析。结果：试验组和对照组在TG减少（WMD=0.883,95%CI=-0.230~1.980,Z=1.560,P=0.120）、TC减少（WMD=-0.060,95%CI=-0.150~0.020,Z=1.520,P=0.130）、HDL减少（WMD=0.040,95%CI=-0.270~0.360,Z=0.270,P=0.790）方面差异均无统计学意义,在LDL减少（WMD=1.080,95%CI=-0.560~2.730,Z=1.290,P=0.020）方面差异有统计学意义。结论：左旋肉碱通过改善肥胖患者的LDL水平,调控肥胖患者脂肪代谢。Aim：To evaluate the relationship between L-carnitine and lipid levels in obese patients .Methods： Ac-cording to the requirements of system evaluation , randomized controlled trials of L-carnitine for weight loss were collected . The quality of the included studies was evaluated and meta-analysis was performed .Results： Reduction in the TG （WMD=0.883,95%CI=-0.230-1.980,Z=1.560,P=0.120）, TC（WMD=-0.060,95%CI=-0.150-0.020, Z=1.520,P=0.130）, and HDL（WMD=0.040,95%CI=-0.270-0.360,Z=0.270,P=0.790） between the inter-vention and control groups had no statistical difference; LDL reduction（WMD=1.080,95%CI=-0.560-2.730,Z=1.290,P=0.020） between the 2 groups had statistical difference .Conclusion：L-carnitine could improve the LDL level of obese patients thus regulating the fat metabolism in obese patients .

关 键 词：左旋肉碱 血脂 肥胖 META分析 

分 类 号：R969.4[医药卫生—药理学]