pH敏感的不对称缩酮引发剂型单体的合成与表征  

Preparation and Characterization of a New pH-Sensitive Biodegradable Inimer

作　　者：刘晓婷[1] 李钟玉[1] 潘跃晓[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325027

出　　处：《化工技术与开发》2015年第3期8-10,30,共4页Technology & Development of Chemical Industry

摘　　要：首次通过不对称缩酮交换方法合成了具有p H敏感前端的缩酮类化合物,在未来的工作中可以用于合成一系列骨架结构具有缩醛键结构的水溶性高分子药物载体。合成的这种化合物,可以与含有巯基或者羟基的抗癌药物通过化学偶联或自组装包埋方式构建具有p H敏感的纳米抗癌药物,以增强抗癌药物的靶向缓释功能,提高药效,减小副作用。In this paper, an acid-sensitive drug delivery inimer was synthesized by a new stratege based on the acetal exchange reaction. It could be synthesized to be a hydrosoluble polymer which contained ketal linkages in its backbone. In the future, this new delivery system should find numerous applications in the field of drug delivery because of its excellent degradation properties.

关 键 词：不对称缩酮交换 引发剂单体 酸降解 

分 类 号：O624.42[理学—有机化学]