贵州省首例输入性B_3基因型麻疹病例的流行病学调查  

Epidemiology of the First Imported B_3 Genotype Measles Case in Guizhou Province

作　　者：杜雯[1] 吴升伟[1] 戴丽芳[1] 徐飞[1] 唐小敏[1] 朱青[1] 周启国 盛卫东 张燕[4] 

机构地区：[1]贵州省疾病预防控制中心,贵阳550004 [2]兴仁县疾病预防控制中心,贵州兴仁562300 [3]黔西南布依族苗族自治州疾病预防控制中心,贵州兴义562400 [4]中国疾病预防控制中心病毒病预防控制所,卫生部医学病毒学和病毒病重点实验室,世界卫生组织西太平洋区麻疹参比实验室,北京100050

出　　处：《中国疫苗和免疫》2015年第1期51-54,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解输入性B_3基因型麻疹病例的流行病学特征和传播情况。方法对1例输入性B_3基因型麻疹病例进行流行病学调查,并采集病例血清和咽拭子标本检测麻疹免疫球蛋白(Immunoglobulin,Ig)M和提取麻疹病毒核酸并测序。结果 2014年在兴仁县发现贵州省首例输入性B_3基因型麻疹病例,该基因型非我国本土流行株。病例血清标本检测结果为麻疹IgM阳性;咽拭子检测到麻疹病毒核酸,测序结果为麻疹病毒B_3基因型。结论此次输入尚未引起进一步的传播,我国目前使用的麻疹减毒活疫苗在人群中的免疫对阻止B_3基因型麻疹病毒传播有效。Objective To understand the epidemiological features and transmission of an imported B3 genotype measles case. Methods An epidemiological study was conducted for 1 imported B3 genotype of measles case; a serum sample and a throat swab were obtained to detect measles immunoglobulin IgM an- tibody and to extract viral ribonucleic acid （RNA） for amplification and sequencing. Results The case was the first imported B3 genotype measles case in Guizhou province Xingren county in 2014. The B3 genotype of measles virus is not the predominant strain in China's Mainland. The serum sample from the case was positive for measles IgM antibody, and viral RNA in the amplified sequence showed B3 geno- type. Conclusion The imported B3 genotype measles virus did not transmit. The current measles-con- taining vaccine in China was effective to protect people from infection.

关 键 词：麻疹病毒 B_3基因型 输入病例 

分 类 号：R511.1[医药卫生—内科学]