99Tcm-MIBI显像在甲状旁腺功能亢进症中的应用及进展  

Application and progress of 99Tcm-MIBI scintigraphy in parathyroidism

作　　者：成钊汀 朱小华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院核医学科,武汉430030

出　　处：《国际放射医学核医学杂志》2015年第1期37-44,共8页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81271600）;湖北省科技计划（2011CDB551）;华中科技大学同济医学院附属同济医院临床新技术、新业务基金（2010026）

摘　　要：99Tcm-MIBI SPECT对甲状旁腺功能亢进症的术前诊断有较高的灵敏度，联合超声或CT能提高诊断和定位的准确率，尤其是对异位的甲状旁腺腺瘤。随着微创甲状旁腺切除术的发展，99Tcm-MIBI SPECT/CT在术前准确定位上的价值日益凸显。甲状旁腺病灶的大小、生化指标等因素会影响99Tcm-MIBI显像的灵敏度和定位准确率。对于部分难以准确诊断和定位的甲状旁腺功能亢进症患者，11C-蛋氨酸PET/CT、四维CT、术中放射导航等是目前的研究热点和发展方向。99Tcm-MIBI SPECT exhibited high sensitivity in hyperparathyroidism. Combination of ultrasound or CT can raise the diagnostic and location accuracy, especially in ectopic parathyroid adenoma. With the development of minimally invasive parathyroidectomy, the value of 99Tcm-MIBI SPECT/CT in preoperative location accuracy stands out. Many factors such as size of the gland lesions and biochemical indexes affect the sensitivity and location accuracy of 99Tcm-MIBI scintigraphy. For the negative imaging hyperparathyroidism patients, 11C-methionine PET/CT, 4D-CT and intraoperative radiation navigation is current research hot spot and development orientation.

关 键 词：甲状旁腺功能亢进症 99M锝甲氧基异丁基异腈 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 

分 类 号：R582.1[医药卫生—内分泌]