^(18)F-FDGPET双探头符合线路显像半定量分析与肺癌病理类型及病灶大小的关系  

Semi-quantitative analysis of ^(18)F-FDG dual-head tomography with coincidence correlated with the pathology and lesion size of lung cancer

作　　者：林琳[1] 郑容[2] 刘琳[1] 贾莹莹[1] 耿建华[1] 陈盛祖[1] 

机构地区：[1]中国医学科学院肿瘤医院核医学科,北京100021 [2]中国医学科学院肿瘤医院PET/CT中心,北京100021

出　　处：《中国医学装备》2015年第3期7-9,共3页China Medical Equipment

基　　金：卫生部部属(管)医院临床学科重点项目(07090010)"图像引导放射治疗的临床应用研究"

摘　　要：目的:探讨肺癌18F-FDG PET双探头符合线路显像半定量指标-肿瘤和(或)正常组织比值(T/N)与病理类型和病灶大小的关系。方法:对65例经病理证实的肺癌患者,行胸部18F-FDG PET双探头符合线路显像。肺癌病灶经2名有经验的核医学医师目测确认后,沿病灶周边勾画感兴趣区,通过与对侧正常肺组织比较计算T/N值;病灶大小=(长轴+短轴+纵轴)÷3。结果:鳞癌组、腺癌组、小细胞癌肺组、细支气管肺泡癌组和类癌组的T/N值分别为9.77±6.73、8.19±3.89、11.28±1.63、2.43±0.04和6.07±0.10。鳞癌、腺癌及小细胞肺癌的T/N比值之间无显著性差异,各种病理类型组间病灶大小差异无显著性,病灶T/N值与病灶大小相关(r=0.366,P=0.003)。将病灶按照大小分为≤3.0 cm组、3.0~4.5 cm组、4.5~6.0 cm组和≥6.0 cm组,各组的T/N值分别为6.35±2.73、10.07±5.00、10.92±7.13和15.12±11.53组间差异有显著性(F=4.989,P=0.004)。3.0~4.5 cm组与4.5~6.0 cm组的T/N值无显著性差异,4.5~6.0 cm组与≥6.0 cm组的T/N值无显著性差异,其他各组间T/N值均有显著性差异(P<0.05)。3例T/N值<2.5的患者中,2例为细支气管肺泡癌,1例为腺癌,腺癌病灶<3.0 cm。结论:鳞癌、腺癌及小细胞肺癌的T/N比值之间无显著性差异,病灶小者T/N值低。Objective： To evaluate the relationship between the tumor/normal tissue ratio（T/N） with pathology and lesion size of lung cancer. Methods： Thoracic 18F-fluorodeoxyglucose（18F-FDG） dual-head tomography imaging with coincidence was performed in 65 patients with lung cancer. The lesions were visualized by two experienced nuclear physicians and the regions of interest（ROI） were drawn. The T/N values were calculated by comparing ROI with the corresponding contralateral normal lung tissue. The size of lesions were calculated by the formula： S=（length of long axis＋ short axis＋ longitudinal axis）/3. Results： The T/N in squamous cell carcinoma, adenocarcinoma, small cell lung carcer, bronchioloalveolar carcinoma, and carcinoid were 9.77±6.73, 8.19±3.89, 11.28±1.63, 2.43±0.04 and 6.07±0.10, respectively. The T/N in bronchioloalveolar carcinoma was smaller than that of squamous cell carcinoma, adenocarcinoma and small cell lung cancer groups（P0.05）; the T/N in carcinoid was smaller than that of squamous cell carcinoma and small cell lung cancer groups（P0.05）. There was no significant difference between other groups（P0.05）. There was no significant difference among lesion sizes of different pathologic group. There was generally correlation between the lesion size and the T/N（r=0.366, P=0.003）. If the lesion size was categorized into ≤3.0cm, 3.0∽4.5cm, 4.5∽6.0cm, ≥6.0cm groups, the T/N were 6.35±2.73, 10.07±5.00, 10.92±7.13, 15.12±11.53, respectively. Significant differences were found among the groups（F=4.989, P=0.004）. No significant difference of the T/N was either found between 3.0∽4.5cm group and 4.5∽6.0cm group, or 4.5∽6.0cm group and≥6.0cm group（P0.05）, significant differences were found between the other groups（P0.05）. Two bronchioloalveolar carcinoma and one adenocarcinoma T/N were less than 2.5. The size of adenocarcinoma was 3.0cm. Conclusion： There is discrepancy of FDG uptake among different pathologic patterns of lung cancer. Ther

关 键 词：肺肿瘤 病理学 体层摄影术 X射线计算机 18F-氟代脱氧葡萄糖 

分 类 号：R817.4[医药卫生—影像医学与核医学]