高粘度骨水泥在治疗骨质疏松性椎体压缩骨折中的临床应用  

The Clinical Application of High Viscosity bone Cement in the Treatment of Osteoporotic Vertebral Compression

作　　者：熊文华[1] 杨云海[1] 林卓锋[1] 

机构地区：[1]广东省深圳市宝安区石岩人民医院骨科,广东深圳518108

出　　处：《河北医学》2015年第5期774-777,共4页Hebei Medicine

基　　金：国家自然科技项目;(编号:W2013ZT083)

摘　　要：目的:将高粘度骨水泥应用于经皮椎体成形术(PVP)治疗骨质疏松性椎体压缩骨折中,并以普通骨水泥为对照,探讨高粘度骨水泥的应用效果及特点。方法:石岩人民医院2014年1月至2015月间骨质疏松性椎体压缩骨折病例50例随机分为两组,各25例,均行PVP手术治疗,研究组给予高粘度骨水泥,对照组给予普通骨水泥。结果:两组间比较,术前Cobb角比较无统计学差异(P>0.05),术后2日和术后6个月研究组Cobb角显著小于对照组(P<0.05);组内比较,两组病例术后Cobb角较术前均有显著降低,术后第2日、术后6个月与术前比较差异具有统计学意义(t=47.700,49.827,39.212,43.303,P<0.01)。两组间比较,术前两组间VAS评分比较无统计学差异(P>0.05),术后研究组第2日和术后6个月VAS评分显著低于对照组(t=28.749,24.713,30.033,29.334,P<0.01);组内比较,两组术后第2日和术后6个月的VAS评分较术前均有显著下降(P<0.05)。两组间比较,术前两组ODI水平比较无统计学差异(P>0.05),术后研究组第2日和术后6个月ODI水平显著低于对照组(t=41.283,44.455,41.124,40.135,P<0.01);组内比较,两组术后第2日和术后6个月的ODI评分较术前均有显著下降(P<0.05)。研究组病例术后6个月并发症发生率2%(2/100),对照组18%(18/100),两组数据间比较差异具有统计学意义(χ2=14.222,P<0.01)。结论:高粘度骨水泥在恢复椎体生理结构及强度、减少渗漏、降低聚合热损伤等方面具有较好的临床效果,可用于骨质疏松性椎体压缩骨折的临床治疗和推广应用。Objective： To discuss the application effect and characteristics of high viscosity bone cement in osteoporotic vertebral compression fractures with percutaneous vertebroplasty（ PVP）. Method： 50 cases of osteoporotic vertebral compression fractures were randomly divided into 2 groups in Shiyan People＇s Hospital from 2014 to Jan2015. 25 cases in study group treated with PVP received high viscosity bone cement and25 cases in control group treated with PVP received ordinary bone cement. Result： The preoperative Cobb angle showed no statistical difference between two groups（ P〉0.05）. Cobb angle postoperative 2 days and 6months in study group was significantly lower than that in control group（ t = 4.286,6.218,P〈0.05）. Cobb angle postoperative 2 days and 6 months was significantly lower than preoperative within study group and within control group（ t = 47.700,49.827,39.212,43.303,P〈0.01）. The preoperative VAS scores showed no statistical difference between two groups（ P〉0. 05）. VAS scores postoperative 2 days and 6 months in study group was significantly lower than that in control group（ t = 1.974,2.577,P〈0.05）. VAS scores postoperative 2 days and 6 months was significantly lower than preoperative within study group and within control group（ t = 41.283,44. 455,41. 124,40. 135,P〈0. 05）. The preoperative ODI levels showed no statistical difference between two groups（ P〉0.05）. ODI levels postoperative 2 days and 6 months in study group was significantly lower than that in control group（ t = 4.286,6.218,P〈0.05）. ODI levels postoperative 2 days and 6 months was significantly lower than preoperative within study group and within control group（ t = 47.700,49.827,39.212,43.303,P〈0.01）. The complication rate of study group was 2%（ 2 / 100）,significantly lower than that of control group 18%（ 18 / 100）（ χ^2= 14.222,P〈0.01）. Conclusion： High viscosity bone cement has good clinical effects in restoration of vertebral body physiological structure and s

关 键 词：高粘度骨水泥 骨质疏松性椎体压缩骨折 聚甲基丙烯酸甲酯 

分 类 号：R687.3[医药卫生—骨科学]