母胎ABO血型不合孕妇IgG抗体效价与新生儿溶血病的关系  

Correlation between Ig G antibody tilter and hemolytic disease of the newborn in pregnant women with maternal-fetal ABO blood type incompatibility

作　　者：周佩珊[1] 黄群[1] 许少榆[1] 

机构地区：[1]揭阳市人民医院妇产科,广东揭阳522000

出　　处：《海南医学》2015年第5期667-669,共3页Hainan Medical Journal

基　　金：广东省医学科研基金(编号:B2010078)

摘　　要：目的探讨母胎ABO血型不合孕妇IgG抗体效价与新生儿溶血病的关系。方法选取2011年3月至2013年11月期间来我院进行产前检查和生育的IgG抗体效价有所升高(≥1:64)的孕妇864例。评价孕妇产前效价并对新生儿溶血病进行检查,确定丈夫血型、孕妇年龄、孕次等因素对孕妇IgG抗体效价分布及胎儿溶血病发生率影响。结果小年龄组662例孕妇中IgG抗体为1:64者261例,IgG抗体≥1:512者46例,而大年龄组202例孕妇中IgG抗体为1:64者35例,IgG抗体≥1:512者68例,其差异均有统计学意义(P<0.05);随着孕妇孕次的增加,效价呈显著升高趋势;新生儿发生溶血病265例中发生贫血97例(36.60%)。结论孕妇年龄和孕次的增加,其效价会增加,新生儿溶血病的发生率也随之增加。Objective To explore the relationship between IgG antibody tilter and hemolytic disease of the newborn in pregnant women with maternal-fetal ABO blood type incompatibility. Methods A total of 864 pregnant women who received prenatal examination with elevated IgG antibody tilter （≥1：64） from March, 2011 to November, 2014 were selected. The prenatal tilter and hemolytic disease of the newborn were evaluated, and the effect of the hus-band blood type and age of pregnant woman gravidity on IgG antibody tilter distribution and the occurrence rate of he-molytic disease of the newborn were explored. Results The IgG tilter was 1：64 in 261 cases and≥1：512 in 46 cases among 662 cases in small age group. The IgG tilter was 1：64 in 35 cases and≥1：512 in 68 cases among 202 cases in big age group. The differences were statistically significant （P〈0.05）. As the increase of gravidity, the tilter was signifi-cantly increased. There were 97 cases had anemia among cases with 265 cases hemolytic disease of the newborn （36.60%）. Conclusion Increase of age and gravidity can increase IgG tilter and occurrence rate of hemolytic disease of the newborn.

关 键 词：ABO血型不合 IGG抗体效价 新生儿 溶血 

分 类 号：R722.18[医药卫生—儿科]