TP-IgM-WB法诊断早期先天梅毒的价值  

Diagnostic value of TP-IgM-WB for early congenital syphilis

作　　者：付金玲[1] 曹玉忠[1] 梁军[2] 

机构地区：[1]东莞市妇幼保健院皮肤科,广东东莞523000 [2]东莞市妇幼保健院检验科,广东东莞523000

出　　处：《海南医学》2015年第5期682-684,共3页Hainan Medical Journal

基　　金：东莞市科技局资助项目(编号:201310515000105)

摘　　要：目的评价梅毒螺旋体蛋白印迹试验(TP-IgM-WB)在诊断早期先天梅毒中的作用。方法对92例梅毒孕妇及其所产93例(1例双胞胎)新生儿血标本行梅毒螺旋体明胶凝聚实验(TPPA)、快速血浆反应素环状卡片试验(RPR)检测和TP-IgM-WB检测,探讨TP-IgM-WB在先天梅毒早期诊断中的价值。结果在梅毒孕妇所生的93例新生儿中,常规综合方法早期诊断先天梅毒26例,TP-IgM-WB法诊断先天梅毒32例,6例TP-IgM-WB血清试验阳性但常规综合方法疑似病例经18个月随访后最终确诊为先天梅毒,两种方法诊断率比较差异具有统计学意义(χ2=0.031)。结论 TP-IgM-WB用于诊断早期先天梅毒优于常规综合诊断法,值得临床推广。Objective To evaluate the role of TP-IgM-WB for the diagnosis of early congenital syph- ilis. Methods Traditional comprehensive approach （TPPA and RPR） and TP-IgM-WB were used to test the sera of 93 neonates born by 92 pregnant women with syphilis. The value of TP-IgM-WB in the diagnosis of early congenital syphilis was investigated. Results In the 93 neonates, 26 were diagnosed as early congenital syphilis by traditional comprehensive approach （TPPA and RPR）, and 32 were diagnosed as early congenital syphilis by TP-IgM-WB. The 6 suspected cases by traditional comprehensive approach with positive serological response to TP-IgM-WB were con- finned as early congenital syphilis finally after 18 months of follow-up. There was a significant difference between the two methods （x2=0.031）. Conclusion The TP-IgM-WB as a diagnostic method for early congenital syphilis is superi- or to traditional comprehensive approach, which deserves clinical expansion.

关 键 词：先天梅毒 梅毒螺旋体蛋白印迹试验 早期诊断 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]