雷公藤临床应用及不良反应的研究进展  

Study progress on clinical application and side effects of Tripterygium wilfordii

作　　者：刘雪梅[1,2] 刘志宏[1] 张晶[1] 池婕 杨丽娜[1] 宋洪涛[1] 

机构地区：[1]南京军区福州总医院药学科,福建福州350025 [2]福建中医药大学药学院,福建福州350108

出　　处：《药学实践杂志》2015年第2期110-113,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(No.81073064);福建省科技计划重大项目(No.2012I1001)

摘　　要：雷公藤临床用于肾病综合征、类风湿关节炎和系统性红斑狼疮等自身免疫性疾病,疗效显著。雷公藤主要对肝、肾和血液系统等引起毒副作用,成为影响其推广使用的主要障碍。对近年来有关雷公藤的临床应用和不良反应的文献报道进行综述,以期为临床应用提供借鉴。Tripterygium wilfordii has been widely used in clinic for the treatment of autoimmune diseases ,such as ne‐phrotic syndrome ,rheumatoid arthritis ,systemic lupus erythematosus ,and the curative effect is significant .But it has toxic and side effects for liver ,kidney ,reproductive system ,etc .The side effects of Tripterygium wilfordii are the main obstacles for the usage and promotion .The literature reports about the clinical application and side effect of Tripterygium wilfordii are reviewed in this paper ,which provides reference for usage in clinic .

关 键 词：雷公藤 临床应用 毒副作用 

分 类 号：R932[医药卫生—生药学]