羧甲基壳聚糖络合碘复合材料的合成和止血活性评价  

Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan

作　　者：李冬冬[1,2] 吴岳林[1,3] 缪震元[3] 张万年[3] 华万森[1] 张火俊[2] 

机构地区：[1]南京理工大学化工学院,江苏南京210094 [2]第二军医大学附属长海医院,上海200433 [3]第二军医大学药学院,上海200433

出　　处：《药学实践杂志》2015年第2期125-126,178,共3页Journal of Pharmaceutical Practice

基　　金：第二军医大学医学专项资助(2011JS14)

摘　　要：目的研究羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料的止血活性。方法在偶氮二异丁腈引发下,以丙烯酸钠、N-乙烯基吡咯烷酮、羧甲基壳聚糖和N,N′-亚甲基双丙烯酰胺为原料制备羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮。然后与碘络合生成羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料,同时进行止血活性测试。结果合成的材料具有很强的吸水性能,平均吸水倍率为103g/g,并且具有很好的耳静脉和股静脉止血效果。结论合成材料的止血效果优于止血海绵和Quikclot。Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan .Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate ,N‐vinylpyrrolidone ,carboxym‐ethyl chitosan and N ,N′‐methylene diacrylamide as the raw materials .It was then complexed with iodine to generate iodine complex with carboxymethyl chitosan ,and the hemostasis activity was tested at the same time .Results The polymers could absorb water with the value of 103g/g and showed potent hemostasis activity for auricular veins and femoral veins .Conclusion The results showed that hemostatic effect of polymers was better than that of hemostatic sponge and Quikclot .

关 键 词：羧甲基壳聚糖 络合碘 止血活性 

分 类 号：R916[医药卫生—药学]