降钙素原在新生儿感染性疾病中的诊断价值  

Diagnostic value of PCT in neonatal infectiou disease

作　　者：张群[1] 赵亮[1] 

机构地区：[1]安徽省太和县中医院检验科,安徽太和236000

出　　处：《中国当代医药》2015年第9期128-130,共3页China Modern Medicine

摘　　要：目的评价血清降钙素原（PCT）在新生儿感染性疾病诊断中的价值。方法选取2012年6月-2013年12月收治的241例新生儿感染性疾病患儿分为细菌组、支/衣原体组和病毒组,并选取同期50例健康新生儿为对照组。采用上转发光免疫层析法检测治疗前后血清PCT水平,乳胶免疫比浊法检测CRP水平,血细胞分析仪检测WBC计数。结果治疗前,细菌组PCT、CRP和WBC水平及阳性率均高于支/衣原体组、病毒感染组及对照组,差异均有统计学意义（P〈0.05）。细菌组PCT阳性率高于CRP和WBC,支/衣原体组和病毒感染组PCT阳性率低于CRP和WBC（P〈0.05）。不同感染组治疗后PCT、CRP和WBC水平均低于治疗前,差异有统计学意义（P〈0.05）。结论血清PCT检测能用于新生儿感染的诊断和鉴别诊断,并能有效反映治疗效果。Objective To evaluate the value of serum procalcitonin（PCT）in the diagnosis of neonatal infectiou disease.Methods 241 cases of neonatal infectiou disease from June 2012 to December 2013 were selected and divided into bacteria group,Mycoplasma/Chlamydia group and viral group.50 healthy neonates were selected as control group in the same period.The level of serum PCT was detected by the up converting luminescence immune chromatography,the level of serum CRP was detected by latex immunonephelometry,the level of serum WBC was detected by hematology analyzer. Results Before treatment,the level and positive rate of PCT,CRP and WBC in bacteria group was higher than that in Mycoplasma/Chlamydia group,viral group and control group respectively,with statistical difference（P〈0.05）.Positive rate of PCT in bacteria group was higher than that of CRP and WBC,positive rate of PCT in Mycoplasma/Chlamydia group and viral group was lower than that of CRP and WBC respectively（P〈0.05）.After treatment,level of PCT,CRP and WBC in different infection group was lower than that before treatment respectively,with statistical difference（P〈0.05）. Conclusion Detection of serum PCT can be used for the diagnosis and differential diagnosis of neonatal infection,and can replay the effect of treatment.

关 键 词：降钙素原 新生儿感染 C-反应蛋白 白细胞计数 

分 类 号：R446.11[医药卫生—诊断学]