钯催化芳烃/烯烃与烯丙酯的氧化Heck交叉偶联反应的最新研究进展  

Recent Developments in Pd-Catalyzed Oxidative Heck Cross Coupling Reaction of Arenes/Alkenes with Allylic Esters

作　　者：尚筱洁[1] 柳忠全[2] 

机构地区：[1]甘肃农业大学资源与环境学院,兰州730070 [2]兰州大学功能有机分子化学国家重点实验室,兰州730000

出　　处：《有机化学》2015年第3期522-527,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21272096;21472080)资助项目~~

摘　　要：芳烃与烯烃通过两分子sp2-C—H键脱氢偶联,构建多取代烯烃的反应称之为氧化Heck反应或脱氢Heck反应,也叫Fujiwara-Moritani反应.在过去的几十年里,由于此类反应直接通过C—H键官能团化形成C—C键而备受关注.然而,绝大多数的此类转化只能适用于缺电子烯烃.富电子烯烃如烯丙酯或烯丙醚类化合物参与的氧化Heck偶联很少被报道.近几年来,我们课题组以及其他研究小组发展了一些十分高效的钯催化芳烃/烯烃与烯丙酯/烯丙醚的氧化脱氢偶联新方法.本文将概述这些有趣的、原子经济的氧化偶联反应的最新研究进展.The cross coupling reaction of arene with alkene generating substituted olefin through two sp2-C—H bond activation is named oxidative Heck reaction, dehydrogenative Heck reaction（DHR）, or Fujiwara-Moritani reaction. In the past decades, these reactions have drawn much attention due to their C—C bond formations via direct C—H functionalization. However, only electron-deficient alkenes are effective coupling partners in most of these systems. The oxidative Heck reaction using electron-rich olefins such as allylic esters and ethers as the coupling partners has rarely been studied. Recently, several novel Pd-catalyzed strategies for cross coupling reactions of arenes/alkenes with allylic esters/ethers have been explored by us and other groups. This review will summarize the developments in this interesting and atom-economic area.

关 键 词：钯催化 氧化Heck反应 烯丙酯 碳氢活化 碳碳键形成 

分 类 号：O621.251[理学—有机化学]