一种N,N-二甲基乙酰胺提供亚甲基在水相中构建亚甲基双酰胺的方法  

Construction of Methylenebisamides in Aqueous Phase Using N,N-Dimethylacetamide to Provide Methylene

作　　者：陈洁[1] 毛金成[1,2] 郑洋[1] 

机构地区：[1]苏州大学材料与化学化工学部,苏州215123 [2]西南石油大学油气藏地质与开发国家重点实验室,成都610500

出　　处：《有机化学》2015年第3期672-675,共4页Chinese Journal of Organic Chemistry

基　　金：教育部留学启动基金;江苏省高校优势学科项目;江苏省有机合成重点实验室基金资助项目~~

摘　　要：双酰胺的结构在合成仿肽类化合物中具有十分重要的作用.以酰胺为底物,N,N-二甲基乙酰胺(DMAC)提供亚甲基,Na2S2O8为氧化剂,NH4)2Ce(NO3)6为催化剂,在水相中反应合成亚甲基双酰胺化合物.采用1H NMR,13C NMR和LRMS对目标产物进行了表征.研究表明该方法具有环境友好,后处理操作简单和产率高等优点,为亚甲基双酰胺化合物提供了新的方法.A variety of bisamides which are key fragments in the formation of peptidomimetic compounds were synthesized. An effective method to synthesize methylenebisamides is by the reaction of amides with N,N-dimethylacetamide（DMAC）using Na2S2O8 as the oxidant and（NH4）2Ce（NO3）6 as the catalyst in water. The structures of product were confirmed by 1H NMR, 13 C NMR and LRMS. The methodology will provide new strategies for the synthesis of methylenebisamides, which has the advantage of environment-friendly, simple workup and high yield.

关 键 词：酰胺 亚甲基双酰胺 水相 

分 类 号：O623.626[理学—有机化学]