无溶剂条件下通过锌铜偶促进的Barbier反应合成羧酸酯  

Synthesis of Esters via Barbier Reaction Mediated by Zinc Copper Couple under Solvent-Free Conditions

作　　者：孟团结[1,2] 黄现强[1] 王进贤[1] 辛丽[1] 

机构地区：[1]西北师范大学化学化工学院,兰州730070 [2]商丘师范学院化学化工学院有机新材料合成重点实验室,商丘476000

出　　处：《有机化学》2015年第3期712-718,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.U1204204)资助项目~~

摘　　要：在锌酮偶的促进下,通过Barbier反应以醛、溴代烃和酸酐为原料,在无溶剂非催化条件下三组分"一锅法"反应合成了一系列高烯丙基酯、高炔丙基酯和β-乙酰氧基酯类化合物.对反应条件及历程也进行了探讨.该方法具有反应条件温和、操作简单、产率高、原料易得、反应迅速的特点.A series of homoallyl esters, homopropargyl esters and β-acetoxyl esters were obtained via Barbier reaction from one pot three component reaction of aldehydes, bromohydrocarbons and anhydrides mediated by zinc copper couple under non-catalytic and solvent-free conditions. The studies on the reaction conditions and the reaction mechanism were also carried out. This protocol has advantages of mild conditions, simple work-up, high yield, easily available starting materials and fast reaction rate.

关 键 词：BARBIER反应 锌铜偶 一锅法 无溶剂 

分 类 号：O623.624[理学—有机化学]