Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics  

作　　者：Yoshihiko Yano Takeshi Azuma Yoshitake Hayashi 

机构地区：[1]Department of Gas-troenterology, Kobe University Graduate School of Medicine [2]Center for Infectious Diseases, Kobe University Graduate School of Medicine

出　　处：《World Journal of Hepatology》2015年第3期583-592,共10页世界肝病学杂志（英文版）（电子版）

基　　金：Supported by A Grant-in-Aid from the Japan Initiative for Global Research Network on Infectious Disease(J-GRID) Program of the Ministry of Education,Culture,Sports,Science and Technology,Japan;a SATREPS Grant from the Japan Science and Technology Agency and the Japan International Cooperation Agency;the Ministry of Health,Labour,and Welfare of Japan,No.H25-general-008

摘　　要：Hepatitis B virus(HBV) infection is major global issue, because chronic HBV infection is strongly associated with liver cancer. HBV spread worldwide with variousmutations and variations. This variability, called quasispecies, is derived from no proof-reading capacity of viral reverse transcriptase. So far, thousands of studies reported that the variety of genome is closely related to the geographic distribution and clinical characteristics. Recent technological advances including capillary sequencer and next generation sequencer have made in easier to analyze mutations. The variety of HBV genome is related to not only antigenicity of HBs-antigen but also resistance to antiviral therapies. Understanding of these variations is important for the development of diagnostic tools and the appropriate therapy for chronic hepatitis B. In this review, recent publications in relation to HBV mutations and variations are updated and summarized.Hepatitis B virus （HBV） infection is major global issue,because chronic HBV infection is strongly associatedwith liver cancer. HBV spread worldwide with variousmutations and variations. This variability, called quasispecies,is derived from no proof-reading capacity ofviral reverse transcriptase. So far, thousands of studiesreported that the variety of genome is closely related tothe geographic distribution and clinical characteristics.Recent technological advances including capillarysequencer and next generation sequencer have made ineasier to analyze mutations. The variety of HBV genomeis related to not only antigenicity of HBs-antigen but alsoresistance to antiviral therapies. Understanding of thesevariations is important for the development of diagnostictools and the appropriate therapy for chronic hepatitisB. In this review, recent publications in relation to HBVmutations and variations are updated and summarized.

关 键 词：HEPATITIS B virus MUTATION QUASISPECIES 

分 类 号：R512.62[医药卫生—内科学]