Imprinted Zac1 in neural stem cells  

作　　者：Guillaume Daniel Udo Schmidt-Edelkraut Dietmar Spengler Anke Hoffmann 

机构地区：[1]Max Planck Institute of Psychiatry,Translational Research

出　　处：《World Journal of Stem Cells》2015年第2期300-314,共15页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Max Planck Institute of Psychiatry

摘　　要：Neural stem cells(NSCs) and imprinted genes play an important role in brain development. On historical grounds, these two determinants have been largely studied independently of each other. Recent evidence suggests, however, that NSCs can reset select genomic imprints to prevent precocious depletion of the stem cell reservoir. Moreover, imprinted genes like the transcriptional regulator Zac1 can fine tune neuronal vs astroglial differentiation of NSCs. Zac1 binds in a sequence-specific manner to pro-neuronal and imprinted genes to confer transcriptional regulation and furthermore coregulates members of the p53-family in NSCs. At the genome scale, Zac1 is a central hub of an imprinted gene network comprising genes with animportant role for NSC quiescence, proliferation and differentiation. Overall, transcriptional, epigenomic, and genomic mechanisms seem to coordinate the functional relationships of NSCs and imprinted genes from development to maturation, and possibly aging.Neural stem cells （NSCs） and imprinted genes playan important role in brain development. On historicalgrounds, these two determinants have been largelystudied independently of each other. Recent evidencesuggests, however, that NSCs can reset select genomicimprints to prevent precocious depletion of the stemcell reservoir. Moreover, imprinted genes like thetranscriptional regulator Zac1 can fine tune neuronalvs astroglial differentiation of NSCs. Zac1 binds ina sequence-specific manner to pro-neuronal andimprinted genes to confer transcriptional regulation andfurthermore coregulates members of the p53-familyin NSCs. At the genome scale, Zac1 is a central hub ofan imprinted gene network comprising genes with animportant role for NSC quiescence, proliferation anddifferentiation. Overall, transcriptional, epigenomic, andgenomic mechanisms seem to coordinate the functionalrelationships of NSCs and imprinted genes fromdevelopment to maturation, and possibly aging.

关 键 词：Zac1 Cell fate decisions Neural stem cells Genomic IMPRINTING Igf2-H19 DLK1 P57 Kip2 NECDIN Differentiation Imprinted gene networks 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]