硫化氢对小鼠皮肤伤口愈合的促进作用  

Hydrogen Sulfide amelioed the healing of mouse skin injury

作　　者：程会军[1] 陈明亮[1] 孙自强[1] 李慧[1] 张磊[1] 王军[1] 吉爱玲[1] 李彦章[1] 

机构地区：[1]河南大学医学院,河南开封475004

出　　处：《河南大学学报（医学版）》2015年第1期32-35,共4页Journal of Henan University:Medical Science

基　　金：国家自然科学基金(31300884);河南省科技厅科技发展计划项目(132300410012);河南省教育厅科学技术研究重点项目(14A310020;14A310021);河南大学科研基金项目(0000A58152;0000A58214;0000A40566);河南大学研究生科研创新(Y1326081;Y1326085)

摘　　要：目的研究外源性H2S对皮肤伤口愈合是否具有促进作用。方法将C57BL/6小鼠随机分为对照组(n=10)和H2S组(n=10)。H2S组小鼠注射H2S供体硫氢化钠(NaHS),剂量为50μmol/次,每天1次;对照组注射等量生理盐水(9g/L NaCl),每天1次;给药10d。给药期间每天观察两组小鼠伤口愈合情况,并在建模后第3、7、9、11天测量伤口大小,计算伤口面积。结果与对照组小鼠相比,硫氢化钠干预使小鼠皮肤伤口愈合时间缩短。结论 H2S能促进小鼠皮肤伤口愈合。Objective To investigate the effects of exogenous Hydrogen Sulfide（H2S）on skin injury in mice.Methods Eight week old male C57BL/6 mice were divided into two groups,which were subjected to skin injury（using 8mm diameter biopsy punch）.The mice from H2 S group（n = 10）were injected one time with NaHS（50μmol/day）intraperitoneally（i.p.）for 10 days,while the mice from control group were administrated（i.p.）with the same amount of saline.The areas of the injury were measured on day1,3,5,7,9,and 11 after the skin injury.All mice were killed at end of the experiments.Results Compared to control mice,the administration of NaHS enhanced the healing of mice skin injury.Conclusion H2 S could enhance the healing of skin injury.

关 键 词：小鼠 皮肤损伤 硫化氢 伤口愈合 

分 类 号：R322.99[医药卫生—人体解剖和组织胚胎学]