血氧水平依赖MR成像对乳腺癌乏氧代谢和疗效评估的研究进展  

The research progress of blood-oxygen-level dependent MR imaging in breast cancer: oxygen metabolism under hypoxic status and curative effect evaluation

作　　者：罗晓瑜[1] 汤光宇[1] 

机构地区：[1]同济大学附属上海第十人民医院放射科,上海200072

出　　处：《国际医学放射学杂志》2015年第2期126-130,共5页International Journal of Medical Radiology

摘　　要：评估乳腺癌乏氧代谢情况和微血管成熟度对临床治疗有指导作用。广泛应用于脑功能研究的血氧水平依赖功能MRI(BOLD-f MRI)可通过静息状态下基线R2*值及任务状态下△R2*值变化评估病灶内部的氧合作用及新生血管成熟度,以监测肿瘤微环境内的乏氧程度,进而制定具有针对性的个体化治疗方案,提高乳腺癌治愈率,降低病死率。就BOLD-f MRI对乳腺癌乏氧代谢、血管成熟度和疗效评估的应用现状进行综述。It has a clinical relevance to assess hypoxic metabolism and microvascular maturity in breast cancer. Being widely used in functional studies of brain blood-oxygen-level dependent contract functional magnetic resonance imaging （BOLD-fMRI） can assess the oxygenation and the maturity of the neovascularization within the lesions through the changes in the R2＊value under the resting state and the△R2＊value under the task state. We may also monitor the hypoxia status within the microenvironment of a tumour and develop a specialised and individualized treatment program to improve the cure rate of breast cancer and reduce mortality rate. Here, we summarized the BOLD-fMRI application status on assessment of oxygen metabolism under hypoxic status in breast cancer, vascular maturity and curative efficacy assessments.

关 键 词：乳腺癌 血氧水平依赖 功能磁共振成像 乏氧代谢 疗效评估 

分 类 号：R445.2[医药卫生—影像医学与核医学]